Aspergixanthones L−T, nine undescribed prenylxanthone derivatives from Aspergillus stellatus

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-01-20 DOI:10.1016/j.phytochem.2025.114413

Yu Liang , Xuanni Chen , Qin Li , Ziming Zhao , Hao Wang , Qingyi Tong , Weiguang Sun , Hucheng Zhu , Yongji Lai , Chunmei Chen , Yonghui Zhang

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Abstract

Nine undescribed prenylxanthone derivatives, aspergixanthones L−T (1−9), were isolated from the fungus Aspergillus stellatus. Compound 4 represents the first propionylated prenylxanthone, while compounds 7−9 are the first examples of prenylxanthones adorned with a 2,3-butanediol group. Their structures with absolute configurations were elucidated based on comprehensive spectroscopic analyses, ECD calculation, single-crystal X-ray diﬀraction, Mo₂(OAc)₄ induced ECD experiment, and Mosherʼs method. Compound 9 showed cytotoxic effects against several human cancer cell lines with the IC₅₀ values ranging from 3.35 ± 0.58 to 8.62 ± 1.18 μM. Compounds 7 and 8 showed suppressive effects on NO production with IC₅₀ values of 7.30 ± 0.69 and 5.16 ± 0.17 μM, respectively.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.