Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate

IF 2.4 2区医学 Q2 SPORT SCIENCES

Journal of Exercise Science & Fitness Pub Date : 2025-01-01 DOI:10.1016/j.jesf.2024.12.006

Ziqing Liu , Jinglin Huang , Min Hu , Xuyan Cui , Lu Leng , Kangle Wang , Jiarui Wu , Shan He , Weiji Deng , Peilun Li , Yilin Chen , Dongdong Gao , Haijie Yu , Junhao Huang

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引用次数: 0

Abstract

Objectives

Our study investigated the effects of acute high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on endothelial function and its associated biomarkers in sedentary young individuals.

Methods

Fifteen subjects (10M / 5F; 22 ± 2 years; BMI: 23.07 ± 4.12 kg/m²) participated in a crossover trial including three experimental conditions: HIIE, MICE, and a control session of rest (CON) in random order separated by a 7-day washout period. Endothelial function was assessed using flow-mediated dilation (FMD), mean shear rate (MSR), and circulating levels of blood lactate, VEGF, IGF-1, and irisin.

Results

Both HIIE and MICE significantly enhanced FMD% (both P < 0.001 and P < 0.01, respectively), lactate (both P < 0.001), VEGF (P < 0.001 and P < 0.01, respectively), IGF-1 (both P < 0.001), and irisin (P < 0.001 and P < 0.05, respectively), with a greater extent after HIIE compared to MICE in FMD% (P < 0.001), MSR (P < 0.05), lactate (P < 0.001), VEGF (P < 0.05), and IGF-1 (P < 0.05). Additionally, change (post-pre) in FMD% was positively correlated with changes in MSR, lactate, and VEGF in both HIIE and MICE conditions. Change in MSR was positively associated with changes in lactate and VEGF in both HIIE and MICE conditions. Furthermore, enhancement in lactate was correlated with enhancements in VEGF in both HIIE and MICE conditions.

Conclusions

Acute HIIE is a more effective method than MICE at improving endothelial function in sedentary young individuals and increases in lactate and its mediated VEGF release, attributed to increase in shear rate after exercise, are involved in regulatory mechanisms.

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在久坐的年轻人中，急性高强度间歇运动在增强内皮功能及其相关生物标志物方面优于中等强度连续运动：乳酸盐可能参与其中。

目的：我们的研究探讨了急性高强度间歇运动（HIIE）和中等强度连续运动（MICE）对久坐年轻人内皮功能及其相关生物标志物的影响。方法：15名受试者(10M / 5F；22±2岁；BMI: 23.07±4.12 kg/m2)参加了交叉试验，包括三种实验条件：HIIE、MICE和对照休息（CON），以随机顺序进行，中间间隔7天的洗脱期。内皮功能通过血流介导扩张（FMD）、平均剪切速率（MSR）、血液乳酸、VEGF、IGF-1和鸢尾素的循环水平进行评估。结果：HIIE和小鼠均能显著提高FMD%（均P P P P P P P P P P P P P P P P）结论：急性HIIE在改善久坐年轻人内皮功能方面比小鼠更有效，运动后乳酸及其介导的VEGF释放的增加，归因于运动后剪切速率的增加，参与了调节机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Exercise Science & Fitness 医学-运动科学

CiteScore

5.10

自引率

3.60%

发文量

审稿时长

31 days

期刊介绍： The Journal of Exercise Science and Fitness is the official peer-reviewed journal of The Society of Chinese Scholars on Exercise Physiology and Fitness (SCSEPF), the Physical Fitness Association of Hong Kong, China (HKPFA), and the Hong Kong Association of Sports Medicine and Sports Science (HKASMSS). It is published twice a year, in June and December, by Elsevier. The Journal accepts original investigations, comprehensive reviews, case studies and short communications on current topics in exercise science, physical fitness and physical education.