Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex.

IF 2.6 4区 医学 Q2 PHYSIOLOGY
Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI:10.1186/s12576-024-00913-8
Sae Uchida, Fusako Kagitani
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引用次数: 0

Abstract

The olfactory bulb receives cholinergic basal forebrain inputs as does the neocortex. With a focus on nicotinic acetylcholine receptors (nAChRs), this review article provides an overview and discussion of the following findings: (1) the nAChRs-mediated regulation of regional blood flow in the neocortex and olfactory bulb, (2) the nAChR subtypes that mediate their responses, and (3) their activity in old rats. The activation of the α4β2-like subtype of nAChRs produces vasodilation in the neocortex, and potentiates olfactory bulb vasodilation induced by olfactory stimulation. The nAChR activity producing neocortical vasodilation was similarly maintained in 2-year-old rats as in adult rats, but was clearly reduced in 3-year-old rats. In contrast, nAChR activity in the olfactory bulb was reduced already in 2-year-old rats. Thus, age-related impairment of α4β2-like nAChR function may occur earlier in the olfactory bulb than in the neocortex. Given the findings, the vasodilation induced by α4β2-like nAChR activation may be beneficial for neuroprotection in the neocortex and the olfactory bulb.

年龄对大鼠嗅球及新皮层烟碱能血流调节的影响。
嗅球和新皮层一样接受基底前脑的胆碱能输入。以烟碱乙酰胆碱受体(nAChR)为重点,本文综述并讨论了以下发现:(1)nAChR介导的新皮层和嗅球区域血流调节;(2)介导其反应的nAChR亚型;(3)它们在老年大鼠中的活性。nAChRs α4β2样亚型的激活使新皮层血管舒张,并增强嗅刺激诱导的嗅球血管舒张。2岁大鼠的nAChR活性与成年大鼠相似,但在3岁大鼠中明显降低。相比之下,2岁大鼠嗅球中的nAChR活性已经降低。因此,与年龄相关的α4β2样nAChR功能损伤可能在嗅球中比在新皮层中更早发生。综上所述,α4β2样nAChR激活引起的血管舒张可能有利于新皮层和嗅球的神经保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
4.30%
发文量
27
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.
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