Application of Self-Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration

IF 3.2 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2025-01-22 DOI:10.1002/jbm.b.35532

Cunliang Guo, Xinyi Jiao, Xiaoxun Du, Tongxing Zhang, Bing Peng, Baoshan Xu

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引用次数: 0

Abstract

Intervertebral disc degeneration (IDD) is one of the leading causes of chronic pain and disability, and traditional treatment methods often struggle to restore its complex biomechanical properties. This article explores the innovative application of self-healing hydrogels in the treatment of IDD, offering new hope for disc repair due to their exceptional self-repair capabilities and adaptability. As a key support structure in the human body, intervertebral discs are often damaged by trauma or degenerative changes. Self-healing hydrogels not only mimic the mechanical properties of natural intervertebral discs but also self-repair when damaged, thereby maintaining stable functionality. This article reviews the self-healing mechanisms and design strategies of self-healing hydrogels and, for the first time, outlines their potential in the treatment of IDD. Furthermore, the article looks forward to future developments in the field, including intelligent material design, multifunctional integration, encapsulation and release of bioactive molecules, and innovative combinations with tissue engineering and stem cell therapy, offering new perspectives and strategies for IDD treatment.

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自愈水凝胶在椎间盘退变治疗中的应用。

椎间盘退变（IDD）是慢性疼痛和残疾的主要原因之一，传统的治疗方法往往难以恢复其复杂的生物力学特性。本文探讨了自修复水凝胶在IDD治疗中的创新应用，由于其卓越的自我修复能力和适应性，为椎间盘修复带来了新的希望。椎间盘作为人体重要的支撑结构，常因外伤或退行性改变而损伤。自修复水凝胶不仅能模拟天然椎间盘的力学特性，而且在受损时也能自我修复，从而保持稳定的功能。本文综述了自愈水凝胶的自愈机制和设计策略，并首次概述了它们在治疗缺乏症中的潜力。展望了该领域的未来发展，包括智能材料设计、多功能集成、生物活性分子的封装和释放，以及与组织工程和干细胞治疗的创新结合，为IDD治疗提供新的视角和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.