How Do Personality Dysfunction and Maladaptive Personality Traits Predict Time to Premature Discontinuation of Pharmacological Treatment of ADHD?

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI:10.1177/10870547241309524

Peter Jacobsson, Tove Granqvist, Christopher J Hopwood, Robert F Krueger, Bo Söderpalm, Thomas Nilsson

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引用次数: 0

Abstract

Objectives: Non-adherence to medication is common in the adult ADHD clinical group. The goal of this pre-registered study was to examine whether the DSM-5 Alternative Model of Personality Disorder (AMPD), generality personality dysfunction (LPFS-BF 2.0) or maladaptive personality traits (PID-5), can predict time to premature discontinuation of pharmacological treatment beyond other known factors.

Methods: A sample of 284 adult patients with ADHD (60.6% female; M_age = 32.31 years) were investigated for medication adherence from 2018 to 2023, using time-to-event analytic methods.

Results: Of the sample, 54 were found to have discontinued treatment prematurely without consulting their physician. Interestingly this group was prescribed considerably lower doses before discontinuation than adhering patients. General personality dysfunction and maladaptive antagonistic personality traits are implicated in varying degrees, with the specific maladaptive personality facets Intimacy Avoidance and Deceitfulness (PID-5) significantly predicting time to premature discontinuation of ADHD medication beyond other known reasons for non-adherence.

Conclusions: The broader implication is that the emerging personality pathology models hold promise to predict non-adherence in the adult ADHD population.

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人格功能障碍和适应不良人格特征如何预测ADHD药物治疗过早停止的时间？

目的：药物不依从性在成人ADHD临床组中很常见。本预注册研究的目的是检验DSM-5人格障碍替代模型（AMPD）、一般性人格功能障碍（LPFS-BF 2.0）或适应不良人格特征（PID-5）是否能在其他已知因素之外预测过早停止药物治疗的时间。方法：284例成年ADHD患者(女性占60.6%；使用时间-事件分析方法，对2018 - 2023年年龄为32.31岁的患者进行药物依从性调查。结果：在样本中，54人被发现在没有咨询医生的情况下过早停止治疗。有趣的是，这组患者在停药前服用的剂量比坚持服药的患者要低得多。一般人格功能障碍和适应不良的对抗性人格特征在不同程度上有关联，特殊的适应不良人格方面亲密回避和欺骗（PID-5）比其他已知的不依从性原因更能显著预测ADHD药物过早停药的时间。结论：更广泛的含义是，新兴的人格病理学模型有望预测成人ADHD人群的不依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.