Plasmatic Levels of Cytokines and Quality of Life among Elderly Individuals with Dizziness.

IF 1 Q3 OTORHINOLARYNGOLOGY
International Archives of Otorhinolaryngology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI:10.1055/s-0044-1791731
Gislaine da Silva Moreira, Luciana Lozza de Moraes Marchiori, Daiane Soares de Almeida Ciquinato, Glória de Moraes Marchiori, Licia Sayuri Tanaka Okamura, Braulio Henrique Magnani Branco, Regina Célia Poli-Frederico
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Abstract

Introduction  Few studies have investigated the relationship between cytokines and dizziness in elderly individuals. Objective  To assess the levels of inflammatory biomarkers and their relationship with quality of life (QoL) among elderly individuals with dizziness. Methods  We conducted a cross-sectional study with 103 participants (90 women and 13 men) who were assessed through the Visual Analogue Scale (VAS) and the Dizziness Handicap Inventory (DHI). The plasma levels of cytokines were measured through the cytometric bead array (CBA) method. Cross-tabulations with the Chi-squared test were used to verify sample homogeneity, and parametric tests were used to analyze the data. Results  Out of the total sample of 103 individuals, dizziness was reported by 40 women and 5 men. A difference between the groups with and without dizziness was observed regarding the levels of interleukin 4 (IL-4; p  = 0.011): the group without dizziness presented a higher mean level (2.1 ± 2.8 pg/mL) when compared to the group that presented dizziness (1.0 ± 1.7 pg/mL). Another difference was found between the DHI classifications and the plasma levels of tumor necrosis factor alpha (TNF-α;) p  = 0.015): the groups without any losses in QoL presented lower TNF-α levels (1.4 pg/mL) compared to the group that presented moderate QoL loss (6.3 pg/mL). Conclusion  Dizziness affects the functional, physical and emotional dimensions of QoL and plays a role in the decrease in the levels of IL-4 and in the presence of fullness and tinnitus. Higher VAS scores are related to dizziness in the elderly. Moreover, the increased levels of TNF-α were associated to light-to-moderate losses in QoL among elderly patients with dizziness.

老年头晕患者血浆细胞因子水平与生活质量的关系。
很少有研究调查细胞因子与老年人头晕之间的关系。目的探讨老年头晕患者炎症标志物水平及其与生活质量的关系。方法采用视觉模拟量表(VAS)和眩晕障碍量表(DHI)对103名参与者(90名女性和13名男性)进行横断面研究。采用细胞计数头阵列(CBA)法检测血浆细胞因子水平。采用交叉表法和卡方检验来验证样本的同质性,并采用参数检验来分析数据。结果在103名患者中,有40名女性和5名男性报告眩晕。在有和没有头晕的组之间观察到白细胞介素4 (IL-4;p = 0.011):无头晕组的平均水平(2.1±2.8 pg/mL)高于有头晕组(1.0±1.7 pg/mL)。DHI分类与血浆肿瘤坏死因子α (TNF-α; p = 0.015)水平之间的另一个差异是:生活质量无损失组的TNF-α水平(1.4 pg/mL)低于生活质量中度损失组(6.3 pg/mL)。结论眩晕影响生活质量的功能、生理和情绪维度,并与IL-4水平下降、饱腹感和耳鸣有关。老年人VAS评分较高与头晕有关。此外,TNF-α水平升高与老年头晕患者轻度至中度生活质量下降有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.80
自引率
0.00%
发文量
84
审稿时长
12 weeks
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