Etiological Insights and the Role of Individual Factors in Infectious Spondylodiscitis.

IF 3.4 Q2 INFECTIOUS DISEASES
Diana Elena Vulpe, Dana-Georgiana Nedelea, Serban Dragosloveanu, Oana Sandulescu, Cristian Scheau
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Abstract

Objectives: Spondylodiscitis can be caused by various microorganisms and has shown a continuous rise in incidence and mortality. The purpose of our study was to analyze the demographic and laboratory data, as well as comorbidities of patients that were surgically treated for spondylodiscitis in our hospital. The causative pathogens involved in the etiology of spinal infections were also assessed. Methods: The study included 92 patients who underwent clinical, radiological, and microbiological analyses including bacterial isolation. According to their culture results, patients were divided into three groups: negative results (n = 29), positive results with Mycobacterium tuberculosis (M. tb.) (n = 26), and positive results with other pathological agents (n = 37). Results: Patients with M. tb. had a significantly lower body mass index (p = 0.022) and were significantly younger (p = 0.024) than the others. The analysis of the complete blood work showed significant differences between the groups regarding fibrinogen levels (p = 0.023), C-reactive protein (p = 0.009), and erythrocyte sedimentation rates (p = 0.042). Results also showed significant differences (p = 0.023) for patients with diabetes mellitus who were more prone to a tuberculosis etiology for their spondylodiscitis compared with patients without the disease. Conclusions: These findings have important implications for adopting individualized treatment strategies underlining the need for identification of patients at high risk for specific causative pathogens.

传染性脊柱炎的病因学见解和个体因素的作用。
目的:脊柱炎可由多种微生物引起,其发病率和死亡率呈持续上升趋势。我们研究的目的是分析我院手术治疗脊柱炎患者的人口学和实验室数据,以及合并症。还评估了脊髓感染病因学中涉及的致病菌。方法:92例患者接受了临床、放射学和微生物学分析,包括细菌分离。根据培养结果将患者分为阴性(n = 29)、结核分枝杆菌阳性(n = 26)和其他病理因子阳性(n = 37)三组。结果:结核分枝杆菌患者;体重指数明显低于其他人(p = 0.022),年龄明显低于其他人(p = 0.024)。全血分析显示,两组间在纤维蛋白原水平(p = 0.023)、c反应蛋白(p = 0.009)和红细胞沉降率(p = 0.042)方面存在显著差异。结果还显示,与没有糖尿病的患者相比,糖尿病患者更倾向于肺结核病因的脊柱椎间盘炎有显著差异(p = 0.023)。结论:这些发现对采取个体化治疗策略具有重要意义,强调了识别特定致病菌高风险患者的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Infectious Disease Reports
Infectious Disease Reports INFECTIOUS DISEASES-
CiteScore
5.10
自引率
0.00%
发文量
82
审稿时长
11 weeks
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