Cadmium levels in maternal blood, placenta, and cord blood in relation to preeclampsia and fetal growth: a case-control study in China

IF 4.3 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Hypertension Research Pub Date : 2025-01-22 DOI:10.1038/s41440-025-02122-1

Weiwei Wu, Bole Zhang, Jing Zhao, Weixuan Hu, Yulin Li, Yongliang Feng, Yawei Zhang, Suping Wang

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Abstract

This study aims to delineate the levels of Cd exposure in maternal blood, placenta, and cord blood, and to explore the association between Cd levels and the risk of preeclampsia (PE), as well as its potential impact on fetal growth among affected individuals. A case-control study was performed at the First Hospital of Shanxi Medical University, involving 373 pregnant women diagnosed with PE and 485 controls. Cd was measured in maternal blood, placenta, and cord blood using ICP-MS. The association between Cd and birth weight z-score was analyzed by multivariate linear regression. Logistic regression analysis was used to investigate the relationships between Cd and the risk of PE, and Cd and the risk of fetal growth. The concentration of Cd in the placenta was higher than that in maternal blood and cord blood. The highest tertile of placental Cd was identified as a risk factor for PE (OR = 2.704, 95% CI: 1.865, 3.921). Among pregnant women with PE, higher levels of Cd exposure in the placenta were negatively associated with birth weight z-scores (per doubling: β = −0.134, 95% CI: −0.264, −0.004), and the highest tertile of placental Cd was associated with an elevated risk of SGA (OR = 2.103, 95% CI: 1.164, 3.801). Furthermore, an interaction between Cd and PE was identified. In conclusion, Cd can accumulate in the placenta of pregnant women, and high placental Cd exposure not only increases the risk of PE but also exacerbates the risk of SGA outcome in PE pregnant women.

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中国孕妇血液、胎盘和脐带血中镉含量与子痫前期和胎儿生长的关系：一项病例对照研究

本研究旨在描述孕妇血液、胎盘和脐带血中Cd暴露水平，并探讨Cd水平与子痫前期（PE）风险之间的关系，以及其对胎儿生长的潜在影响。在山西医科大学第一医院进行病例对照研究，纳入373例确诊为PE的孕妇和485例对照。采用ICP-MS测定母血、胎盘和脐带血中的Cd。采用多元线性回归分析Cd与出生体重z-score之间的关系。采用Logistic回归分析探讨Cd与PE风险、Cd与胎儿生长风险的关系。胎盘中Cd浓度高于母血和脐带血。胎盘Cd的最高分位数被确定为PE的危险因素（OR = 2.704, 95% CI: 1.865, 3.921）。在PE孕妇中，胎盘中较高水平的Cd暴露与出生体重z分数呈负相关（每翻倍：β = -0.134, 95% CI: -0.264, -0.004），胎盘中最高的Cd含量与SGA风险升高相关（OR = 2.103, 95% CI: 1.164, 3.801）。此外，还鉴定了Cd和PE之间的相互作用。综上所述，Cd可在孕妇胎盘中积累，胎盘高Cd暴露不仅会增加PE的风险，还会加剧PE孕妇发生SGA结局的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension Research 医学-外周血管病

CiteScore

7.40

自引率

16.70%

发文量

249

审稿时长

3-8 weeks

期刊介绍： Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.