Five new triterpenoids isolated from mastic: Structural identification and their anti-inflammatory activity.

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-20 DOI:10.1016/j.fitote.2025.106395

Wentian Xiang, Yangkai Luo, Xuerui An, Ting He, Ping Cai, Minawar Kurban, Wei Liu, Tao Yuan

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引用次数: 0

Abstract

Five new oleanane-type triterpenoids were isolated from mastic. Their structures including absolute configurations were determined by extensive spectroscopic methods and single-crystal X-ray crystallographic experiments. Compound 1 is distinguished by its rare furan ring. Compounds 3-5 are formed by the oxidative ring-opening reaction of the A ring in oleanane-type triterpenes, while compounds 3 and 4 are nor-triterpenes with a carbon atom missing at the C-28 position. The anti-inflammatory potential of the compounds was anticipated through network pharmacology, followed by a detailed molecular docking analysis. Finally, the anti-inflammatory effects were verified through the establishment of an in vitro model. Notably, compounds 3 and 4 exhibited significant inhibitory effects on NO production in RAW264.7 cells induced by lipopolysaccharide, with IC₅₀ values of 8.68 ± 2.58 and 5.00 ± 3.06 μM, respectively. These values are lower than that of the positive control drug, dexamethasone, which has an IC₅₀ of 9.93 ± 1.17 μM. The significant anti-inflammatory activity of these compounds suggests their potential as treatment candidates for inflammatory diseases.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.