Efficacy of Poloxamer 188 in Carboplatin-Induced Aplastic Anemia Model in CBA Mice.

Q3 Agricultural and Biological Sciences

Doklady Biological Sciences Pub Date : 2025-01-22 DOI:10.1134/S0012496624600428

A V Bervinova, V A Palikov, N A Borozdina, I N Kravchenko, I A Pakhomova, R A Dalevich, S Z Hajiguliyeva, E V Arshintseva, S Yu Pushkin, I A Dyachenko, A N Murashev

引用次数: 0

Abstract

Poloxamer 188 (P188) was tested for effect on medullary hematopoiesis in aplastic anemia. P188 was administered to CBA mice with developing anemia via oral gavage at doses of 10, 100, and 500 mg/kg. A dose-dependent effect was observed, including an increase in erythrocyte count, hemoglobin, and reticulocyte count. The parameters remained low and suggested mild anemia on day 21 in a group treated with carboplatin. P188 was assumed to exert a beneficial effect on the blood cell composition, which is distorted by cytostatic drugs.

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来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.