Surgery versus radiotherapy for older patients (aged≥65 years) with stage I-II laryngeal cancer: an investigational study from the SEER database.

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2025-02-01 Epub Date: 2025-01-25 DOI:10.1080/14737140.2025.2458159

Wangyan Zhong, Xueying Jin, Ting Li, Jiwei Mao, Hang Yuan, Jiangfeng Feng

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引用次数: 0

Abstract

Background: Currently, the choice between radiotherapy and surgery for treating older patients with early laryngeal cancer remains unclear. The aim of this retrospective study is to investigate the therapeutic patterns and survival outcomes for a cohort of older patients with early laryngeal cancer who received radiation therapy (RT) or surgery.

Methods: Clinical records of 1833 patients aged 65+ with stage I/II laryngeal cancer from the SEER registry (2010-2015) were assessed. Of these, 1319 underwent RT and 514 had surgery alone. Kaplan-Meier analysis assessed overall survival (OS) and cancer-specific survival (CSS), with Log-rank tests for comparison.

Results: The 5-year OS and CSS rates were 61.1% and 80.6%, respectively. Univariate analysis showed age, gender, T stage, histology, and treatment as prognostic factors for OS and CSS. Multivariate analysis linked age, T stage, and treatment to OS, and gender, histology, T stage, and treatment to CSS. Surgery improved OS and CSS for most early-stage patients, except those with grade III cancer.

Conclusion: Among early-stage laryngeal cancer patients aged 65 years or older reported in the SEER database, those treated with surgery experienced longer OS and CSS compared to those treated with RT, except for patients with grade III.

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老年I-II期喉癌患者（年龄≥65岁）的手术与放疗：来自SEER数据库的一项调查研究。

背景：目前，老年早期喉癌患者放疗与手术的选择尚不明确。本回顾性研究的目的是调查一组接受放射治疗（RT）或手术的老年早期喉癌患者的治疗模式和生存结果。方法：对2010-2015年SEER登记的1833例65岁以上I/II期喉癌患者的临床记录进行评估。其中，1319人接受了RT， 514人单独接受了手术。Kaplan-Meier分析评估总生存期（OS）和癌症特异性生存期（CSS），采用Log-rank检验进行比较。结果：5年OS和CSS率分别为61.1%和80.6%。单因素分析显示，年龄、性别、T分期、组织学和治疗是OS和CSS的预后因素。多变量分析将年龄、T分期和治疗与OS联系起来，将性别、组织学、T分期和治疗与CSS联系起来。除了III级癌症患者外，手术改善了大多数早期患者的OS和CSS。结论：在SEER数据库中报告的65岁及以上的早期喉癌患者中，除III级患者外，接受手术治疗的患者比接受RT治疗的患者经历了更长的OS和CSS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.