Meta-Analysis of the Association Between VEGF-2578C/A Polymorphism and Susceptibility to Type 2 Diabetic Retinopathy.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Current Eye Research Pub Date : 2025-01-22 DOI:10.1080/02713683.2025.2451616

Dingyong Wu, Wanting Li

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引用次数: 0

Abstract

Purpose: to investigate the association between vascular endothelial growth factor (VEGF)-2578C/A polymorphism and susceptibility to type 2 diabetic retinopathy (T2DR) by meta-analysis.

Methods: According to the search strategy, Four databases were retrieved to identify the literature on the relationship between VEGF polymorphism and the risk of T2DR from inception to July 2024. Stata 15.0 was used for data processing.

Results: Ten articles were involved in this review, covering 1390 cases and 1306 controls. The pooled results exhibited that the risk of T2DR was associated with VEGF-2578C/A polymorphism under the allele model (A/C: OR= 1.33, 95%CI: 1.04-1.72, p = 0.025) and dominant models (AA+CA/CC: OR= 1.38, 95%CI: 1.00-1.91, p = 0.047). However, in recessive, homozygous, and heterozygous models, no significant difference was observed (all p > 0.05).

Conclusions: The VEGF-2578C/A polymorphism is associated with susceptibility to T2DR. In particular, allele A and genotype AA+CA at the VEGF-2578C/A locus were significantly associated with an increased risk of T2DR.

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VEGF-2578C/A多态性与2型糖尿病视网膜病变易感性相关性的meta分析

目的：通过荟萃分析探讨血管内皮生长因子(VEGF)-2578C/A多态性与2型糖尿病视网膜病变（T2DR）易感性的关系。方法：根据检索策略，检索4个数据库，检索自成立以来至2024年7月关于VEGF多态性与T2DR风险关系的文献。数据处理采用Stata 15.0。结果：本综述纳入10篇文章，涵盖1390例病例和1306例对照。综合结果显示，在等位基因模型（A/C: OR= 1.33, 95%CI: 1.04 ~ 1.72, p = 0.025）和显性模型（AA+CA/CC: OR= 1.38, 95%CI: 1.00 ~ 1.91, p = 0.047）下，T2DR风险与VEGF-2578C/A多态性相关。然而，在隐性、纯合子和杂合子模型中，没有观察到显著差异（均p < 0.05）。结论：VEGF-2578C/A多态性与T2DR易感性相关。特别是，VEGF-2578C/A基因座的等位基因A和基因型AA+CA与T2DR风险增加显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.