Meta-Analysis of the Association Between VEGF-2578C/A Polymorphism and Susceptibility to Type 2 Diabetic Retinopathy.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Current Eye Research Pub Date : 2025-01-22 DOI:10.1080/02713683.2025.2451616

Dingyong Wu, Wanting Li

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引用次数: 0

Abstract

Purpose: to investigate the association between vascular endothelial growth factor (VEGF)-2578C/A polymorphism and susceptibility to type 2 diabetic retinopathy (T2DR) by meta-analysis.

Methods: According to the search strategy, Four databases were retrieved to identify the literature on the relationship between VEGF polymorphism and the risk of T2DR from inception to July 2024. Stata 15.0 was used for data processing.

Results: Ten articles were involved in this review, covering 1390 cases and 1306 controls. The pooled results exhibited that the risk of T2DR was associated with VEGF-2578C/A polymorphism under the allele model (A/C: OR= 1.33, 95%CI: 1.04-1.72, p = 0.025) and dominant models (AA+CA/CC: OR= 1.38, 95%CI: 1.00-1.91, p = 0.047). However, in recessive, homozygous, and heterozygous models, no significant difference was observed (all p > 0.05).

Conclusions: The VEGF-2578C/A polymorphism is associated with susceptibility to T2DR. In particular, allele A and genotype AA+CA at the VEGF-2578C/A locus were significantly associated with an increased risk of T2DR.

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.