Altered retinal vasculature in childhood cancer survivors: Data from the German CVSS-study.

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Alexander K Schuster, Anna Maria Voigt, Tamara Jäger, Stefan Nickels, Andreas Schulz, Jörg Faber, Arthur Wingerter, Hiltrud Merzenich, Irene Schmidtmann, Manfred E Beutel, Thomas Münzel, Karl J Lackner, Norbert Pfeiffer, Philipp S Wild
{"title":"Altered retinal vasculature in childhood cancer survivors: Data from the German CVSS-study.","authors":"Alexander K Schuster, Anna Maria Voigt, Tamara Jäger, Stefan Nickels, Andreas Schulz, Jörg Faber, Arthur Wingerter, Hiltrud Merzenich, Irene Schmidtmann, Manfred E Beutel, Thomas Münzel, Karl J Lackner, Norbert Pfeiffer, Philipp S Wild","doi":"10.1111/aos.17438","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>Childhood cancer is a risk factor for cardiovascular diseases in later life. Retinal examination allows to non-invasively observe the vasculature of an end-organ. We observe alterations in long-term childhood cancer survivors (CCS).</p><p><strong>Methods: </strong>In the Cardiac and Vascular Late Sequelae in Long-Term Survivors of Childhood Cancer-Study, 1002 CCS (23-48 years) having neoplasia prior to 15 years of age were prospectively enrolled in a general and ophthalmologic examination including fundus photography. Central retinal vessel equivalents (arterial: CRAE; venous CRVE) were measured and linear regression analysis was computed to compare CCS to controls from the population-based Gutenberg Health Study (GHS) with adjustment for potential cardiovascular and ophthalmological confounders. Differences in cancer types and treatments were explored.</p><p><strong>Results: </strong>For 837 CCS (45.3% female), CRAE and CRVE were conducted. Both were smaller in CCS previously having leukaemia, central nervous system tumour, neuroblastoma, renal tumour, malignant bone tumour, soft tissue sarcoma and germ cell tumour than in GHS controls. No difference was found for CCS with prior lymphoma. Previous radiotherapy of head or neck was associated with a smaller CRVE. Higher mean arterial blood pressure and intake of antihypertensive medication were associated with smaller CRAE.</p><p><strong>Conclusions: </strong>Retinal vasculature is altered in CCS leading to smaller retinal arteries and veins. Our finding indicates that childhood cancer and its treatment leads to systemic alterations of the microcirculation on both branches of the vasculature system. While the retinal venous vasculature is altered by radiotherapy, the lower vessel width of the arterial branch is associated with arterial hypertension.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/aos.17438","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Aims: Childhood cancer is a risk factor for cardiovascular diseases in later life. Retinal examination allows to non-invasively observe the vasculature of an end-organ. We observe alterations in long-term childhood cancer survivors (CCS).

Methods: In the Cardiac and Vascular Late Sequelae in Long-Term Survivors of Childhood Cancer-Study, 1002 CCS (23-48 years) having neoplasia prior to 15 years of age were prospectively enrolled in a general and ophthalmologic examination including fundus photography. Central retinal vessel equivalents (arterial: CRAE; venous CRVE) were measured and linear regression analysis was computed to compare CCS to controls from the population-based Gutenberg Health Study (GHS) with adjustment for potential cardiovascular and ophthalmological confounders. Differences in cancer types and treatments were explored.

Results: For 837 CCS (45.3% female), CRAE and CRVE were conducted. Both were smaller in CCS previously having leukaemia, central nervous system tumour, neuroblastoma, renal tumour, malignant bone tumour, soft tissue sarcoma and germ cell tumour than in GHS controls. No difference was found for CCS with prior lymphoma. Previous radiotherapy of head or neck was associated with a smaller CRVE. Higher mean arterial blood pressure and intake of antihypertensive medication were associated with smaller CRAE.

Conclusions: Retinal vasculature is altered in CCS leading to smaller retinal arteries and veins. Our finding indicates that childhood cancer and its treatment leads to systemic alterations of the microcirculation on both branches of the vasculature system. While the retinal venous vasculature is altered by radiotherapy, the lower vessel width of the arterial branch is associated with arterial hypertension.

儿童癌症幸存者视网膜血管改变:来自德国cvss研究的数据。
目的:儿童癌症是晚年心血管疾病的危险因素。视网膜检查可以无创地观察终末器官的血管系统。我们观察了长期儿童癌症幸存者(CCS)的变化。方法:在儿童癌症长期幸存者的心脏和血管晚期后遗症研究中,1002名在15岁之前患有肿瘤的CCS(23-48岁)前瞻性地参加了包括眼底摄影在内的一般和眼科检查。视网膜中央血管当量(动脉:CRAE;测量静脉CRVE),并计算线性回归分析,将CCS与基于人群的古登堡健康研究(GHS)的对照进行比较,并校正潜在的心血管和眼科混杂因素。探讨了癌症类型和治疗方法的差异。结果:837例CCS患者(女性45.3%)行cre和CRVE检查。在患有白血病、中枢神经系统肿瘤、神经母细胞瘤、肾肿瘤、恶性骨肿瘤、软组织肉瘤和生殖细胞肿瘤的CCS患者中,两者都比GHS对照组小。CCS合并既往淋巴瘤患者无差异。既往头部或颈部放疗与较小的CRVE相关。较高的平均动脉血压和抗高血压药物的摄入与较小的CRAE相关。结论:CCS患者视网膜血管系统发生改变,导致视网膜动静脉变小。我们的发现表明,儿童癌症及其治疗导致微循环的系统性改变在两个分支的血管系统。当视网膜静脉血管被放疗改变时,动脉分支的较低血管宽度与动脉高血压有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信