Rings of death: How NINJ1 executes plasma membrane rupture

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-01-23 DOI:10.1016/j.cell.2024.12.030

Zhonghua Liu, Tsan Sam Xiao

引用次数: 0

Abstract

Plasma membrane rupture during lytic cell death was previously believed to occur through passive osmosis that burst open the membrane. Recent publications, including one in this issue of Cell, suggest that plasma membrane rupture is an active process mediated by ninjurin-1 (NINJ1) oligomers that dissolve membranes and/or assemble large pores.

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死亡之环：NINJ1如何执行质膜破裂

在溶解性细胞死亡过程中，质膜破裂以前被认为是通过被动渗透使膜破裂而发生的。最近的出版物，包括本期《细胞》杂志上的一篇文章，表明质膜破裂是一个由ninjurin-1 （ninjurin-1）低聚物介导的活跃过程，该低聚物溶解膜和/或组装大孔。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.