Metabolism and metabolites regulating hematopoiesis

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-01-18 DOI:10.1016/j.coi.2025.102525

Baihao Zhang , Sidonia Fagarasan

引用次数: 0

Abstract

Energy metabolism of immune cells, such as glycolysis and mitochondrial activity, requires strict regulation. This is especially critical in the complex environment of the bone marrow (BM), where there is a need to both preserve the quiescence of hematopoietic stem cells (HSCs) and guarantee timed and effective lineage differentiation of the HSCs. Recent advances highlight the critical roles played by bioactive metabolites in regulating hematopoiesis. In particular, secreted immune metabolites (SIMets), such as γ-aminobutyric acid (GABA) and acetylcholine, secreted by B-lineage cells, act as potent modulators of hematopoietic processes, influencing HSC differentiation and emergency hematopoiesis. In this review, we provide an overview and discuss mechanisms by which energy metabolism and SIMets regulate hematopoiesis. We propose that biochemical communication facilitated by these metabolites is essential for maintaining the BM niche and suggest potential therapeutic strategies using SIMets in hematological disorders.

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代谢和代谢产物调节造血。

免疫细胞的能量代谢，如糖酵解和线粒体活性，需要严格调节。这在复杂的骨髓环境（BM）中尤为重要，在骨髓环境中，既需要保持造血干细胞（hsc）的静止，又需要保证造血干细胞及时有效的谱系分化。近年来的研究进展强调了生物活性代谢物在调节造血过程中所起的关键作用。特别是，分泌免疫代谢物（SIMets），如γ-氨基丁酸（GABA）和乙酰胆碱，由b系细胞分泌，作为造血过程的有效调节剂，影响造血干细胞分化和紧急造血。在这篇综述中，我们提供概述并讨论了能量代谢和simet调节造血的机制。我们提出由这些代谢物促进的生化通讯对于维持BM生态位至关重要，并提出了使用simmets治疗血液疾病的潜在治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.