Retrospective evaluation of the incidence and outcome of neutropenia in dogs with acute hemorrhagic diarrhea syndrome (2017–2022): 54 cases

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2025-01-20 DOI:10.1111/vec.13448

Cormac Dolan MVB, Neus Elias Santo-Domingo LMV, DECVECC

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引用次数: 0

Abstract

Objective

To report the occurrence of neutropenia in dogs with suspected acute hemorrhagic diarrhea syndrome (AHDS) and to assess its association with survival. Secondary objectives were to assess whether neutropenia was associated with length of hospitalization, fulfillment of systemic inflammatory response syndrome (SIRS) criteria, and whether SIRS status was associated with survival. Finally, the association of antimicrobial use with neutropenia, SIRS status, and survival was evaluated.

Design

Single-center, retrospective study from the medical records of dogs diagnosed with AHDS between 2017 and 2022.

Setting

Private referral hospital.

Animals

Fifty-four dogs with suspected AHDS referred to the Emergency and Critical Care specialist service.

Interventions

None.

Measurements and Main Results

Of 54 dogs, 28 (52%) presented with or developed neutropenia during their treatment course. Overall, 9 (17%) dogs were nonsurvivors. A total of 8 of 28 (29%) dogs with neutropenia were nonsurvivors, while only 1 of 26 (4%) dogs with a normal neutrophil count was a nonsurvivor (P = 0.025). Upon hospital admission, neutropenic dogs were significantly more likely to fulfill SIRS criteria than nonneutropenic dogs (P = 0.0096). There was no difference in mortality between SIRS-positive (fulfilling ≥2 SIRS criteria) and SIRS-negative (fulfilling <2 SIRS criteria) dogs (P = 0.14). There was no difference in the median length of hospitalization between neutropenic and nonneutropenic dogs (P = 0.49).

Conclusions

The incidence of neutropenia is high in this population of dogs presenting with AHDS. In this retrospective study, neutropenia was significantly associated with an increased risk of nonsurvival and an increased likelihood of fulfilling SIRS criteria; however, a fulfillment of SIRS criteria could not be used to predict survival. Neutropenia in dogs with AHDS was not associated with an increased length of hospitalization.

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急性出血性腹泻综合征犬中性粒细胞减少发生率及转归回顾性分析（2017-2022）：54例

目的：报道疑似急性出血性腹泻综合征（AHDS）犬中性粒细胞减少症的发生情况，并探讨其与生存的关系。次要目的是评估中性粒细胞减少是否与住院时间、是否满足全身性炎症反应综合征（SIRS）标准有关，以及SIRS状态是否与生存有关。最后，评估抗菌药物使用与中性粒细胞减少症、SIRS状态和生存的关系。设计：从2017年至2022年诊断为AHDS的狗的医疗记录中进行单中心回顾性研究。环境：私人转诊医院。动物：54只疑似AHDS的狗被转介至紧急及重症护理专科服务。干预措施:没有。测量和主要结果：54只狗中，28只（52%）在治疗过程中出现或发生中性粒细胞减少症。总的来说，9只（17%）狗没有幸存下来。28只中性粒细胞减少犬中有8只（29%）未存活，而26只中性粒细胞计数正常的犬中只有1只（4%）未存活（P = 0.025）。入院时，中性粒细胞减少的狗比非中性粒细胞减少的狗更有可能满足SIRS标准（P = 0.0096）。SIRS阳性（满足≥2个SIRS标准）和SIRS阴性（满足结论：在出现AHDS的犬群中，中性粒细胞减少的发生率很高）之间的死亡率没有差异。在这项回顾性研究中，中性粒细胞减少与无法生存的风险增加和满足SIRS标准的可能性增加显著相关；然而，满足SIRS标准不能用于预测生存。AHDS犬的中性粒细胞减少与住院时间的增加无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.