Polycystic ovary syndrome and morphokinetic embryonic development: A case-control study evaluating 791 embryos.

F&S science Pub Date : 2025-01-19 DOI:10.1016/j.xfss.2025.01.003

Gilad Karavani, Shira Shapira-Nass, Natali Schachter-Safrai, Tal Imbar, Assaf Ben-Meir

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Abstract

Objective: To investigate the association between Polycystic Ovary Syndrome (PCOS) and the rate of embryo development, using time-lapse monitoring systems (TLM), compared to a control group of women with mechanical (tubal) factor infertility.

Design: A retrospective case-control study conducted in a university affiliated IVF unit.

Patients: Women with PCOS undergoing in-vitro fertilization (IVF) treatments and those with non-PCOS controls with tubal factor infertility only. Development morphokinetic milestones were compared and analysis of covariance for time to distinct cell number as well as logistic mixed models to determine predictors for embryos over the 75^th percentile was performed.

Exposure: Not applicable.

Main outcome measures: Embryo development morphokinetic parameters in women with and without PCOS undergoing IVF treatments.

Results: The study included 791 embryos from 115 women, 364 embryos from 52 women with PCOS and 427 embryos from 63 women with non-PCOS controls with tubal factor infertility. The PCOS group was 4 years younger (30.07±6.03 vs. 34.08±4.84 years, p=0.002) and had higher number of oocytes retrieved (16.00 vs. 11.00, p<0.001), mature oocytes (11.00 vs. 7.00,<0.001) and fertilized oocytes (8.00 vs. 5.00, p<0.001). The PCOS and control groups demonstrated comparable clinical pregnancy rates (55.8% vs. 32.1%,p=0.053), miscarriage rate (12.5% vs. 11.8%, p=0.994) and live birth rate (48,8% vs. 31.2%, p=0.089). Morphokinetic parameters were comparable between the groups. While age was associated with later time to 5 and 8 discrete cells and start of blastulation (tSB), PCOS was only associated with later tSB, including tSB>75^th percentile.

Conclusion: This study demonstrated comparable IVF outcomes in women with PCOS and non-PCOS controls. An analysis of TLM data from these patients showed no evidence that PCOS negatively affects embryonic development rate in women undergoing IVF cycles.

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多囊卵巢综合征与形态动力学胚胎发育：791个胚胎的病例对照研究。

目的：应用延时监测系统（TLM）探讨多囊卵巢综合征（PCOS）与机械性（输卵管）因素不孕妇女胚胎发育速率的关系。设计：在一所大学附属试管婴儿单位进行的回顾性病例对照研究。患者：接受体外受精（IVF）治疗的多囊卵巢综合征（PCOS）妇女和仅伴有输卵管因素不孕的非PCOS对照者。对发育形态动力学里程碑进行了比较，并对不同细胞数量的时间协方差进行了分析，并对逻辑混合模型进行了分析，以确定超过75百分位的胚胎预测因子。暴露：不适用。主要观察指标：接受体外受精治疗的多囊卵巢综合征和非多囊卵巢综合征妇女的胚胎发育形态动力学参数。结果：该研究包括115名妇女的791个胚胎，52名多囊卵巢综合征妇女的364个胚胎和63名非多囊卵巢综合征妇女输卵管性不孕的427个胚胎。PCOS组比PCOS组年轻4岁（30.07±6.03岁比34.08±4.84岁，p=0.002），取卵数较高（16.00比11.00,p= 75百分位）。结论：本研究证明了多囊卵巢综合征和非多囊卵巢综合征对照妇女的IVF结果相当。对这些患者TLM数据的分析显示，没有证据表明多囊卵巢综合征对接受试管婴儿周期的妇女的胚胎发育率有负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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