Physical function, functional capacity, cognition, and brain structure and function in older adults with chronic kidney disease (CKD)

IF 2.5 3区医学 Q3 GERIATRICS & GERONTOLOGY

Geriatric Nursing Pub Date : 2025-03-01 DOI:10.1016/j.gerinurse.2024.12.035

Mary F. Hannan PhD , Olu Ajilore MD, PhD , Xiaohong Joe Zhou PhD , James P. Lash MD , Qingfei Luo PhD , Ulf G. Bronas PhD

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引用次数: 0

Abstract

Objective

To evaluate associations between brain structure/function with physical function and functional capacity in older adults with CKD and cognitive complaints.

Methods

We evaluated associations between neuroimaging and cognitive function with functional capacity and physical function in older adults (60–80years) with CKD and cognitive complaints (n = 39; age 67.6 years).

Results

In multivariable analysis, each standard deviation (SD) increase in 6-minute walk test (6MWT) distance (functional capacity) was associated with better attention/information processing (Trails Making Test-A (TMT-A) (ß -10.86, 95% Confidence Interval (CI) -16.67, -5.06); digit symbol test (ß 5.24, 95% CI 1.02, 9.46)), and each SD increase in short physical performance battery (SPPB)(physical function) was associated with better attention/information processing (TMT-A) (ß -10.99, 95% CI -16.59, -5.39). 6MWT distance and SPPB were associated with some indicators of brain structure/diffusivity.

Conclusion

In older adults with CKD and cognitive complaints, functional capacity and physical function may be associated with cognition and brain structure/function.

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老年慢性肾脏疾病（CKD）患者的身体功能、功能能力、认知、脑结构和功能

目的：评估老年CKD患者脑结构/功能与身体功能和功能能力之间的关系。方法：我们评估了患有CKD和认知疾病的老年人（60-80岁）的神经影像学和认知功能、功能能力和身体功能之间的关系(n = 39；年龄67.6岁)。结果：在多变量分析中，6分钟步行测试（6MWT）距离（功能能力）每增加一个标准差（SD）与更好的注意/信息处理（Trails Making test - a, TMT-A）相关（ß -10.86, 95%置信区间(CI) -16.67, -5.06）；数字符号测试（ß 5.24, 95% CI 1.02, 9.46）)，短物理性能电池（SPPB）（物理功能）每增加一个SD与更好的注意/信息处理（TMT-A）相关（ß -10.99, 95% CI -16.59, -5.39）。6MWT距离和SPPB与脑结构/弥散性的一些指标相关。结论：在老年CKD患者中，功能能力和身体功能可能与认知和脑结构/功能有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geriatric Nursing 医学-护理

CiteScore

3.80

自引率

7.40%

发文量

257

审稿时长

>12 weeks

期刊介绍： Geriatric Nursing is a comprehensive source for clinical information and management advice relating to the care of older adults. The journal''s peer-reviewed articles report the latest developments in the management of acute and chronic disorders and provide practical advice on care of older adults across the long term continuum. Geriatric Nursing addresses current issues related to drugs, advance directives, staff development and management, legal issues, client and caregiver education, infection control, and other topics. The journal is written specifically for nurses and nurse practitioners who work with older adults in any care setting.