Systemic factors associated with antler growth promote complete wound healing.

IF 6.4 1区医学 Q1 CELL & TISSUE ENGINEERING

npj Regenerative Medicine Pub Date : 2025-01-21 DOI:10.1038/s41536-025-00391-5

Qianqian Guo, Guokun Zhang, Jing Ren, Jiping Li, Zhen Wang, Hengxing Ba, Zihao Ye, Ying Wang, Junjun Zheng, Chunyi Li

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Abstract

Deer antlers are the only mammalian appendages that can fully regenerate from periosteum of pedicles (PP). This regeneration process starts from regenerative healing of wounds. Removal of PP abolishes antler regeneration, however, the regenerative cutaneous wound healing proceeds, indicating that some factors in the circulation contribute to this healing. In this study, we produced a wound in the scalp of deer either in antler regeneration period (ARP) (n = 3) or in non-ARP (n = 3). Results showed full regeneration took place only when the wound was created during ARP. Interestingly, topical application of systemic factors from ARP (n = 9) promoted regenerative wound healing in rats. Comparative proteomics analysis (n = 3) revealed that PRG4 and IGF-1 were high during ARP, and topical application of PRG4 + IGF-1 promoted restoration in rat FTE wounds. We believe that, ultimately, incorporating systemic factors into advanced wound care modalities could offer new opportunities for regenerative healing in the clinical setting.

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与鹿角生长有关的全身因素促进伤口完全愈合。

鹿角是哺乳动物中唯一能完全由蒂骨膜再生的附属物。这种再生过程始于伤口的再生愈合。然而，再生皮肤伤口愈合继续进行，表明循环中的某些因素有助于这种愈合。在这项研究中，我们在鹿角再生期（n = 3）和非鹿角再生期（n = 3）的鹿头皮上制造了一个伤口。结果表明，只有在ARP过程中创面才会发生完全再生。有趣的是，局部应用来自ARP的系统性因子（n = 9）促进了大鼠的再生伤口愈合。比较蛋白质组学分析（n = 3）显示，ARP期间PRG4和IGF-1水平较高，局部应用PRG4 + IGF-1促进大鼠FTE伤口修复。我们相信，最终，将系统因素纳入先进的伤口护理模式可以为临床环境中的再生愈合提供新的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.