Knee loading and joint pain during daily activities in people with knee osteoarthritis: A systematic review and meta-analysis

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-02-01 DOI:10.1016/j.clinbiomech.2025.106433

Yi Wan , Polly McGuigan , James Bilzon , Logan Wade

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引用次数: 0

Abstract

Background

Knee loading is associated with the severity and progression of knee osteoarthritis, while knee pain contributes to reduced functional ability and quality of life. In this systematic review, we quantified knee loading and knee pain during different daily activities in people with knee osteoarthritis and explored methodological reasons for differences between studies.

Methods

PubMed, Web of Science, Scopus, and manual searches were performed up to July 2024, to retrieve studies measuring knee loading and knee pain in walking, sit-to-stand and stair climbing of people with knee osteoarthritis. Descriptive data synthesis and meta-analysis were performed using a mixed-effect model.

Findings

183 studies were included. Walking led to the greatest knee loading, followed by stair climbing and finally sit-to-stand, although only sit-to-stand was significantly lower than the others (p < 0.001). Stair ascent had the greatest knee pain, followed by walking, stair descent and then sit-to-stand. In addition, our results show a strong negative correlation between knee loading and pain during walking (r = −0.507).

Interpretation

The trend of knee loading across activities, while non-significant, is consistent with our previous experimental study. The differences compared to other studies are likely be due to the high heterogeneity in the tested population and differences in methodology. Additionally, there were a substantial number of studies only examining a single activity (primarily walking), which could bias the results. Therefore, future studies should detail participant characteristic and experiment design. In addition, inclusion of a control group is recommended to account for knee loading offsets when comparing results across studies.

查看原文本刊更多论文

膝关节骨关节炎患者日常活动中的膝关节负荷和关节疼痛：一项系统回顾和荟萃分析。

背景：膝关节负荷与膝关节骨关节炎的严重程度和进展有关，而膝关节疼痛会导致功能能力和生活质量的降低。在这篇系统综述中，我们量化了膝关节骨关节炎患者在不同日常活动中的膝关节负荷和膝关节疼痛，并探讨了研究之间差异的方学原因。方法：通过PubMed、Web of Science、Scopus和人工检索，检索膝关节骨性关节炎患者在行走、坐立和爬楼梯时膝关节负荷和膝关节疼痛的研究。描述性数据综合和meta分析采用混合效应模型。结果：纳入183项研究。步行导致最大的膝关节负荷，其次是爬楼梯，最后是坐立，尽管只有坐立明显低于其他活动(p)解释：膝关节负荷的趋势，虽然不显著，但与我们之前的实验研究一致。与其他研究相比，差异可能是由于受测人群的高度异质性和方法的差异。此外，有相当数量的研究只检查了一项活动（主要是散步），这可能会使结果产生偏差。因此，未来的研究应详细描述参与者特征和实验设计。此外，在比较研究结果时，建议纳入一个对照组，以考虑膝关节负荷偏移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.