Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts.

IF 4.8 2区医学 Q1 GERIATRICS & GERONTOLOGY

Journals of Gerontology Series B-Psychological Sciences and Social Sciences Pub Date : 2025-03-12 DOI:10.1093/geronb/gbaf006

Antonio Terracciano, Keenan A Walker, Yang An, Murat Bilgel, Angelina R Sutin, Martina Luchetti, Selin Karakose, Yannick Stephan, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Przemysław R Kac, Abhay R Moghekar, Madhav Thambisetty, Luigi Ferrucci, Susan M Resnick

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引用次数: 0

Abstract

Objectives: Loneliness is associated with an elevated risk of dementia. There is mixed evidence from imaging studies on whether loneliness is associated with neuropathology in dementia-free adults. This study tests whether loneliness is associated with plasma neurobiomarkers of amyloid (Aβ42/Aβ40), phosphorylated tau 181 (pTau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) and imaging measures of amyloid and tau.

Methods: Participants were cognitively unimpaired older adults from the Baltimore Longitudinal Study on Aging (BLSA; N = 1,028 individuals and up to 2,277 neurobiomarker measurements; Baseline mean age = 66, SD = 15 years) and the UK Biobank (N = 1,263 individuals and up to 2,526 neurobiomarker measurements; Baseline mean age = 60, SD = 7 years). Single-item measures of loneliness and the Quanterix Single Molecule Array assays were used in both samples. In a subset of BLSA participants, positron emission tomography (PET) was used to assess cerebral amyloid burden (n = 220) and tau in the entorhinal cortex (n = 102).

Results: In both samples and meta-analyses, loneliness was unrelated to plasma measures of Aβ42/Aβ40, pTau181, NfL, and GFAP. Changes in loneliness were also unrelated to changes in the plasma neurobiomarkers, and no consistent evidence of moderation by age, sex, or APOE ε4 allele was found. Loneliness was also unrelated to PET-based measures of amyloid and tau.

Discussion: This study found no associations between loneliness and measures of Alzheimer's disease pathology, axonal damage, or astrogliosis.

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阿尔茨海默病、轴突损伤和星形胶质增生的孤独和生物标志物：两个纵向队列的协调分析。

目的：孤独与痴呆风险升高有关。在无痴呆的成年人中，关于孤独是否与神经病理学相关的影像学研究证据不一。本研究测试了孤独感是否与淀粉样蛋白（Aβ42/Aβ40）、磷酸化tau 181 （pTau181）、神经丝轻链（NfL）和胶质纤维酸性蛋白（GFAP）的血浆神经生物标志物以及淀粉样蛋白和tau的成像指标有关。方法：参与者是来自巴尔的摩老龄化纵向研究(BLSA；N= 1028个个体和多达2277个神经生物标志物测量；基线平均年龄=66岁，SD=15岁)和UK Biobank (N=1,263个人和多达2,526个神经生物标志物测量；基线平均年龄=60岁，SD=7岁)。在两个样本中使用了孤独感的单项测量和Quanterix单分子阵列测定。在一部分BLSA参与者中，正电子发射断层扫描（PET）用于评估大脑淀粉样蛋白负荷（n=220）和内嗅皮层的tau蛋白（n=102）。结果：在样本和荟萃分析中，孤独感与血浆中a- β42/ a- β40、pTau181、NfL和GFAP的测定无关。孤独感的变化也与血浆神经生物标志物的变化无关，并且没有发现与年龄、性别或APOE ε4等位基因有关的一致证据。孤独感也与基于PET的淀粉样蛋白和tau蛋白测量无关。讨论：本研究未发现孤独感与阿尔茨海默病病理、轴突损伤或星形胶质细胞增生之间存在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journals of Gerontology Series B-Psychological Sciences and Social Sciences 医学-老年医学

CiteScore

11.60

自引率

8.10%

发文量

178

审稿时长

6-12 weeks

期刊介绍： The Journal of Gerontology: Psychological Sciences publishes articles on development in adulthood and old age that advance the psychological science of aging processes and outcomes. Articles have clear implications for theoretical or methodological innovation in the psychology of aging or contribute significantly to the empirical understanding of psychological processes and aging. Areas of interest include, but are not limited to, attitudes, clinical applications, cognition, education, emotion, health, human factors, interpersonal relations, neuropsychology, perception, personality, physiological psychology, social psychology, and sensation.