The effect of continuous positive airway pressure therapy on intraocular pressure in patients with OSA: a systematic review and meta-analysis.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Clinical Sleep Medicine Pub Date : 2025-01-16 DOI:10.5664/jcsm.11552

Papan Kongchan, Wish Banhiran, Niphon Chirapapaisan, Navarat Kasemsuk

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引用次数: 0

Abstract

Study objectives: To assess the effect of continuous positive airway pressure (CPAP) therapy on intraocular pressure in Obstructive sleep apnea (OSA) patients.

Methods: The search was performed in Ovid Medline and Embase database then followed by a manual bibliography search. Abstract search and screening were independently performed followed by eligible full-text versions reviewed. Then disagreements were discussed in a group.

Results: This systematic review and meta-analysis considered 15 studies with 495 participants. The pooled mean intraocular pressure after CPAP therapy shows no significant difference compared to the baseline (MD, 0.58 mmHg; 95% CI, -0.33 to 1.19). Subgroup analysis shows significantly higher intraocular pressure after in-lab PAP titration and after long-term CPAP used (MD, 4.28 mmHg; 95% CI, 0.91 to 7.66; MD, 0.45 mmHg; 95% CI, 0.07 to 0.83; respectively). Ocular perfusion pressure was also significantly decreased after CPAP therapy. (MD, -2.15 mmHg; 95% CI, -3.50 to -0.80). The pooled data showed no significant difference in RNFL thickness and macular layer thickness.

Conclusions: After long-term treatments CPAP therapy, there is a significant increase in intraocular pressure in patients with OSA and a decrease in ocular perfusion pressure but did not show a significant difference in other ophthalmologic parameters. For this reason, CPAP usage in glaucoma patients necessitates to be done cautiously.

Systematic review registration: This systematic review protocol was registered with PROSPERO (registration number CRD42022370734).

查看原文本刊更多论文

持续气道正压治疗对OSA患者眼压的影响：一项系统综述和荟萃分析。

研究目的：评价持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停（OSA）患者眼压的影响。方法：在Ovid Medline和Embase数据库中检索，然后手工检索文献。摘要检索和筛选独立进行，然后审查符合条件的全文版本。然后在一个小组中讨论分歧。结果：本系统综述和荟萃分析纳入了15项研究，495名参与者。CPAP治疗后的综合平均眼压与基线相比无显著差异(MD, 0.58 mmHg；95% CI, -0.33 ~ 1.19)。亚组分析显示，实验室滴入PAP和长期使用CPAP后眼压显著升高(MD, 4.28 mmHg；95% CI, 0.91 ~ 7.66；MD, 0.45 mmHg；95% CI, 0.07 ~ 0.83；分别)。CPAP治疗后眼灌注压也明显降低。(MD, -2.15 mmHg；95% CI, -3.50 ~ -0.80)。合并数据显示RNFL厚度和黄斑层厚度无显著差异。结论：经长期CPAP治疗后，OSA患者眼压明显升高，眼灌注压明显降低，但其他眼科参数无显著差异。因此，在青光眼患者中使用CPAP必须谨慎。系统评价注册：本系统评价方案在PROSPERO注册（注册号CRD42022370734）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Sleep Medicine CLINICAL NEUROLOGY-

CiteScore

6.20

自引率

7.00%

发文量

321

审稿时长

1 months

期刊介绍： Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.