Association between the triglyceride glucose-body mass index and memory-related diseases: A nationwide cohort study.

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2025-01-17 DOI:10.1016/j.puhe.2024.12.046

Xiaoyan Ni, Yiwei Zhang, Weixian Zhang, Yi Wen, Yujing Wang, Mingmin Wang

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引用次数: 0

Abstract

Objectives: This study aimed to examine the longitudinal association between the triglyceride glucose-body mass index (TyG-BMI) index and memory-related diseases (MDs) among Chinese adults.

Study design: Nationwide cohort study.

Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), which is an ongoing nationally representative prospective cohort study. The exposure was the participants' TyG-BMI index at baseline from 2011 to 2012. MDs were acquired by self-reporting questions in 2018. Cox proportional hazards regression models were conducted to assess the relationship between the TyG-BMI index and MDs.

Results: During a median follow-up of 7.0 years, a total of 197 incident MDs events occurred. After multivariate adjustments for established MD-related risk factors, participants with the highest tertile of the TyG-BMI index had a higher risk of MDs (HR: 1.65; 95 % CI: 1.02-2.09; P-trend <0.001) relative to individuals with the lowest tertile. Furthermore, the subgroup analyses of the association remained consistent.

Conclusion: A high TyG-BMI index was associated with an increased risk of MDs. Our study suggests that monitoring long-term changes in the TyG-BMI index could assist with the early identification and prevention of MDs among individuals at high risk.

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甘油三酯-葡萄糖-体重指数与记忆相关疾病的关系：一项全国性队列研究

目的：本研究旨在探讨中国成年人甘油三酯-葡萄糖-体重指数（TyG-BMI）指数与记忆相关疾病（MDs）的纵向关系。研究设计：全国队列研究。方法：数据来自中国健康与退休纵向研究（CHARLS），这是一项正在进行的具有全国代表性的前瞻性队列研究。暴露量是参与者2011年至2012年基线时的TyG-BMI指数。2018年md是通过自我报告问题获得的。采用Cox比例风险回归模型评估TyG-BMI指数与MDs之间的关系。结果：在中位随访7.0年期间，共发生197例MDs事件。在对确定的md相关危险因素进行多因素调整后，TyG-BMI指数最高的参与者患md的风险更高(HR: 1.65；95% ci: 1.02-2.09；结论：高TyG-BMI指数与MDs风险增加相关。我们的研究表明，监测TyG-BMI指数的长期变化有助于在高危人群中早期识别和预防MDs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.