A study of the risk factors for Ureaplasma urealyticum infection and the predictive role of immunoinflammation.

IF 1.4 4区 医学 Q4 INFECTIOUS DISEASES
Yanhui Li, Jie Zheng, Junpeng Zhao, Wenjie Qi, Yuhong Yao, Dongxue Gao, Jinyin Yan
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Abstract

Introduction: Despite increasing awareness on the prevention of Ureaplasma urealyticum (Uu) infection, the high-risk factors responsible for infection in female patients in China are yet to be determined.

Methodology: The study included 3043 Chinese women. Cervical secretion samples were collected for Uu identification.

Results: Higher age groups (25-30, 30-35, 35-40, and >40 years) had a higher risk of Uu infection (OR = 1.46; OR = 1.51; OR = 1.71; OR = 2.49, respectively). Being literate, and use of intrauterine device (IUD), or other contraceptive methods could reduce the risk of Uu infection (OR = 0.64; OR = 0.79; OR = 0.76, respectively). Women with low level of cleanliness or promiscuous behavior had a higher risk of Uu infection (OR = 1.42; OR = 1.41, respectively). Among the Uu-positive patients, 66.84%, 24.81%, and 8.35% were infected with biovars 1, 2, and coinfection. The predominant subtypes were S6 serotypes (28.91%) in biovar 1 and S2` subtypes (62.73%) in biovar 2. The possibility of S1 + S6 infection was lower than that in S1 patients (OR = 0.529). C-reactive protein (CRP) and systemic immune inflammation index (SII) could be used to predict Uu infection (area under curve, AUC = 0.55; AUC = 0.68, respectively).

Conclusions: Uu-positive patients were infected with two biovars and multiple subtypes. Age, method of contraception, cleanliness, education level, promiscuity, and subtypes of Uu were factors influencing Uu infection. CRP and SII provide a new strategy for clinical diagnosis of Uu infection.

解脲支原体感染危险因素及免疫炎症预测作用的研究。
导读:尽管人们对预防解脲支原体(Uu)感染的认识不断提高,但导致中国女性患者感染的高危因素尚未确定。方法:研究对象为3043名中国女性。采集宫颈分泌物标本进行Uu鉴定。结果:年龄越大年龄组(25-30岁、30-35岁、35-40岁和40岁以下)Uu感染的风险越高(OR = 1.46;Or = 1.51;Or = 1.71;OR = 2.49)。识字、使用宫内节育器(IUD)或其他避孕方法可降低Uu感染的风险(or = 0.64;Or = 0.79;OR = 0.76)。清洁程度低或有滥交行为的妇女感染Uu的风险较高(or = 1.42;OR = 1.41)。在uu阳性患者中,66.84%、24.81%和8.35%的患者感染1型、2型和合并感染。生物多样性1的主要亚型为S6亚型(28.91%),生物多样性2的主要亚型为S2 '亚型(62.73%)。S1 + S6感染的可能性低于S1患者(OR = 0.529)。c反应蛋白(CRP)和全身免疫炎症指数(SII)可用于预测Uu感染(曲线下面积,AUC = 0.55;AUC = 0.68)。结论:uu阳性患者感染有两种生物变体和多亚型。年龄、避孕方法、洁净度、文化程度、性乱交和Uu亚型是影响Uu感染的因素。CRP和SII为临床诊断Uu感染提供了新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
5.30%
发文量
239
审稿时长
4-8 weeks
期刊介绍: The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.
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