Vaping—An Emerging Threat to Youngsters of Pakistan

IF 2.6 3区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Nazish Jaffar, Hafiza Tooba Siddiqui, Huda Amin, Md Ariful Haque
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Studies have shown that e-cigarettes can be harmful to human health, particularly among teenagers whose brains and respiratory systems are still developing [<span>2</span>]. An interesting study was published in your esteemed journal, <i>Addiction Biology</i>, on the neural performance of abstinent smokers. It aimed to find out the alterations in the brain networks. Before and after using e-cigarettes, this experiment revealed that the impact of e-cigarettes could be similar to neural activity caused by traditional cigarettes and other forms, which may lead to addiction [<span>3</span>].</p><p>To begin with, it is essential to understand that e-cigarettes contain nicotine, which can lead to addiction and dependency similar to regular tobacco products. Studies suggest that vaping can expose users to higher levels of nicotine than traditional smoking, as well as other harmful chemicals such as formaldehyde and acetaldehyde. These chemicals are known carcinogens and could cause long-term harm to the respiratory system (Figure 1). This shows the average exposure to substances used in e-cigarettes. To calculate the chemical exposure from tobacco-related items, a study was performed where the toxicological threshold for margins of exposure (MOE) for each chemical was determined as MOE &lt; 10 as ‘high risk’. At the same time, MOE &lt; 100 was judged as ‘risk’. More than 100 were acceptable. In this experiment, nicotine showed (a margin of exposure) MOE &lt; 1, making it fall in the high-risk category [<span>3, 4</span>]. Therefore, increasing public awareness about the potential risks of using e-cigarettes is crucial.</p><p>Moreover, there is increasing evidence linking e-cigarette use with cardiovascular risk factors such as high blood pressure and impaired heart function. Nicotine plays an integral role in these risks by constricting arteries and narrowing blood vessels, thereby reducing oxygen supply throughout the body and leading to damage over time [<span>5</span>]. As the trends in everything change, social media is a new platform where businesses market their products in the marketing industry. One of its ways is how influencers are positively marketing E-cigarettes with no age restrictions and no trigger warning related to their adverse effects. In countries like Asia and the US, most of the followers are youngsters aged 13–17, which will ultimately expose them to the greater risk of adopting this culture. As a recent study showed, Generation Z generally perceives influencers as credible and authentic sources of information [<span>6, 7</span>].</p><p>Another area of concern surrounding vaping pertains to individuals who have never smoked before trying their hands at vaping. Studies have suggested that adolescents who take up e-cigarettes are more likely to go on smoking combustible cigarettes or other forms of tobacco products later on in life than those who do not vape. E-cigarettes are heavily promoted in Pakistan via print and electronic media as a risk-free alternative to smoking regular cigarettes or as a tool for quitting smoking. Electronic cigarettes are sold to people of all ages in many stores and supermarkets across Pakistan's major cities, including Karachi, Lahore and Islamabad. Many tobacco businesses openly promote these new tobacco products to the young Pakistani population because there is no legislation governing e-cigarettes [<span>8</span>]. According to reports, 19.1% of the Pakistani population are smokers, out of which 6.2% use e-cigarettes, while 15.9 million (12.4%) use smokeless tobacco [<span>9</span>]. One of the studies showed an alarming 10.7% prevalence of smoking in teenage boys and girls aged between 13–15 years in the Pakistani population [<span>10</span>].</p><p>In conclusion, the risks associated with vaping are numerous and potentially harmful—from increased nicotine exposure levels to long-term respiratory and cardiovascular risks. Therefore, raising general public awareness through educational initiatives alongside sensible policymaking will help protect both present and future generations from potential harm associated with e-cigarette use. Such awareness campaigns could include education and cessation programs targeted towards youths and leveraging social media platforms for better outreach.</p><p>We recommend that policymakers in Pakistan must take a data-driven approach to regulating e-cigarettes. This would involve conducting further research studies on the effects of vaping on human health and how effectively it can prevent the onset of addiction or dependency. 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引用次数: 0

Abstract

We would like to draw your attention to a critical prevailing issue regarding the usage of e-cigarettes and their ill effects on health. E-cigarettes have been marketed as a safer alternative to traditional tobacco products, but research has shown that they still pose significant health risks. Studies have revealed that the chemical compounds in e-cigarettes can cause damage to the lungs, heart and nervous system [1].

With the boom in vaping culture, many people believe that e-cigarettes are a healthier alternative to traditional cigarettes. However, research studies have shown otherwise. Studies have shown that e-cigarettes can be harmful to human health, particularly among teenagers whose brains and respiratory systems are still developing [2]. An interesting study was published in your esteemed journal, Addiction Biology, on the neural performance of abstinent smokers. It aimed to find out the alterations in the brain networks. Before and after using e-cigarettes, this experiment revealed that the impact of e-cigarettes could be similar to neural activity caused by traditional cigarettes and other forms, which may lead to addiction [3].

To begin with, it is essential to understand that e-cigarettes contain nicotine, which can lead to addiction and dependency similar to regular tobacco products. Studies suggest that vaping can expose users to higher levels of nicotine than traditional smoking, as well as other harmful chemicals such as formaldehyde and acetaldehyde. These chemicals are known carcinogens and could cause long-term harm to the respiratory system (Figure 1). This shows the average exposure to substances used in e-cigarettes. To calculate the chemical exposure from tobacco-related items, a study was performed where the toxicological threshold for margins of exposure (MOE) for each chemical was determined as MOE < 10 as ‘high risk’. At the same time, MOE < 100 was judged as ‘risk’. More than 100 were acceptable. In this experiment, nicotine showed (a margin of exposure) MOE < 1, making it fall in the high-risk category [3, 4]. Therefore, increasing public awareness about the potential risks of using e-cigarettes is crucial.

Moreover, there is increasing evidence linking e-cigarette use with cardiovascular risk factors such as high blood pressure and impaired heart function. Nicotine plays an integral role in these risks by constricting arteries and narrowing blood vessels, thereby reducing oxygen supply throughout the body and leading to damage over time [5]. As the trends in everything change, social media is a new platform where businesses market their products in the marketing industry. One of its ways is how influencers are positively marketing E-cigarettes with no age restrictions and no trigger warning related to their adverse effects. In countries like Asia and the US, most of the followers are youngsters aged 13–17, which will ultimately expose them to the greater risk of adopting this culture. As a recent study showed, Generation Z generally perceives influencers as credible and authentic sources of information [6, 7].

Another area of concern surrounding vaping pertains to individuals who have never smoked before trying their hands at vaping. Studies have suggested that adolescents who take up e-cigarettes are more likely to go on smoking combustible cigarettes or other forms of tobacco products later on in life than those who do not vape. E-cigarettes are heavily promoted in Pakistan via print and electronic media as a risk-free alternative to smoking regular cigarettes or as a tool for quitting smoking. Electronic cigarettes are sold to people of all ages in many stores and supermarkets across Pakistan's major cities, including Karachi, Lahore and Islamabad. Many tobacco businesses openly promote these new tobacco products to the young Pakistani population because there is no legislation governing e-cigarettes [8]. According to reports, 19.1% of the Pakistani population are smokers, out of which 6.2% use e-cigarettes, while 15.9 million (12.4%) use smokeless tobacco [9]. One of the studies showed an alarming 10.7% prevalence of smoking in teenage boys and girls aged between 13–15 years in the Pakistani population [10].

In conclusion, the risks associated with vaping are numerous and potentially harmful—from increased nicotine exposure levels to long-term respiratory and cardiovascular risks. Therefore, raising general public awareness through educational initiatives alongside sensible policymaking will help protect both present and future generations from potential harm associated with e-cigarette use. Such awareness campaigns could include education and cessation programs targeted towards youths and leveraging social media platforms for better outreach.

We recommend that policymakers in Pakistan must take a data-driven approach to regulating e-cigarettes. This would involve conducting further research studies on the effects of vaping on human health and how effectively it can prevent the onset of addiction or dependency. As part of such an approach, policymakers could also consider implementing stricter regulations on marketing practices aimed at promoting e-cigarette usage among minors, particularly on social media marketing, as it is spreading the use of E-cigarettes among people who were previously non-smokers.

Nazish Jaffar provided critical insights, finalized the manuscript and performed a rigorous critical review to enhance its quality. Hafiza Tooba Siddiqui undertook the initial drafting of the letter, shaping the core message and structure. Huda Amin conceived the idea and conducted an extensive literature search, laying the foundation for the letter. Md Ariful Haque assisted in the final review process and managed correspondence with the journal, ensuring seamless communication and compliance with submission requirements.

The authors have nothing to report.

The authors have nothing to report.

The authors declare no conflicts of interest.

Abstract Image

电子烟——巴基斯坦青少年面临的新威胁。
我们想提请您注意关于电子烟的使用及其对健康的不良影响的一个关键的普遍问题。电子烟作为一种比传统烟草产品更安全的替代品在市场上销售,但研究表明,它们仍然构成重大的健康风险。研究表明,电子烟中的化合物会对肺、心脏和神经系统造成损害。随着电子烟文化的兴起,许多人认为电子烟是传统香烟更健康的替代品。然而,研究表明并非如此。研究表明,电子烟对人体健康有害,尤其是对大脑和呼吸系统仍在发育的青少年。一项有趣的研究发表在你们尊敬的杂志《成瘾生物学》上,是关于戒烟者的神经表现。它的目的是找出大脑网络的变化。在使用电子烟前后,该实验揭示了电子烟的影响可能与传统香烟和其他形式引起的神经活动相似,可能导致成瘾。首先,有必要了解电子烟含有尼古丁,尼古丁会导致上瘾和依赖,就像普通烟草产品一样。研究表明,电子烟会让使用者接触到比传统吸烟更高水平的尼古丁,以及其他有害化学物质,如甲醛和乙醛。这些化学物质是已知的致癌物,可能对呼吸系统造成长期危害(图1)。这显示了电子烟中使用的物质的平均暴露量。为了计算来自烟草相关物品的化学暴露,进行了一项研究,其中每种化学物质的暴露边际(MOE)的毒理学阈值被确定为MOE &lt; 10,即“高风险”。同时,MOE &lt; 100被判定为“风险”。超过100个是可以接受的。在本实验中,尼古丁显示(暴露边际)MOE &lt; 1,属于高危类别[3,4]。因此,提高公众对使用电子烟潜在风险的认识至关重要。此外,越来越多的证据表明,使用电子烟与高血压和心脏功能受损等心血管风险因素有关。尼古丁在这些风险中起着不可或缺的作用,它会收缩动脉和血管,从而减少全身的氧气供应,并随着时间的推移导致损伤。随着一切趋势的变化,社交媒体是营销行业企业营销产品的新平台。其中一种方式是网红如何积极营销电子烟,没有年龄限制,也没有与其不利影响相关的触发警告。在亚洲和美国等国家,大多数粉丝都是13-17岁的年轻人,这最终将使他们面临更大的接受这种文化的风险。最近的一项研究表明,Z世代普遍认为网红是可信和真实的信息来源[6,7]。与电子烟有关的另一个问题是那些从未吸过烟的人在尝试吸电子烟。研究表明,与不吸电子烟的青少年相比,吸电子烟的青少年更有可能在以后的生活中继续吸可燃香烟或其他形式的烟草产品。巴基斯坦通过印刷和电子媒体大力推广电子烟,将其作为吸普通卷烟的无风险替代品或戒烟工具。在巴基斯坦主要城市,包括卡拉奇、拉合尔和伊斯兰堡,许多商店和超市都向所有年龄段的人出售电子烟。许多烟草企业公开向巴基斯坦年轻人推销这些新型烟草产品,因为巴基斯坦没有监管电子烟的立法。据报道,巴基斯坦19.1%的人口是吸烟者,其中6.2%使用电子烟,而1590万人(12.4%)使用无烟烟草。其中一项研究显示,巴基斯坦13-15岁的青少年男女吸烟率高达10.7%。总之,与电子烟相关的风险很多,而且可能有害——从尼古丁暴露水平增加到长期呼吸和心血管风险。因此,通过教育举措和明智的政策制定来提高公众意识,将有助于保护今世后代免受电子烟使用带来的潜在危害。此类宣传活动可以包括针对年轻人的教育和戒烟计划,并利用社交媒体平台进行更好的宣传。我们建议巴基斯坦的政策制定者必须采取数据驱动的方法来监管电子烟。 这将涉及对电子烟对人类健康的影响以及它如何有效地预防成瘾或依赖进行进一步的研究。作为这种方法的一部分,政策制定者还可以考虑对旨在促进未成年人使用电子烟的营销行为实施更严格的监管,特别是在社交媒体营销方面,因为它正在将电子烟的使用传播到以前不吸烟者的人群中。Nazish Jaffar提供了关键的见解,完成了手稿,并进行了严格的批判性审查,以提高其质量。Hafiza Tooba Siddiqui负责了这封信的最初起草工作,塑造了核心信息和结构。胡达·阿明构思了这个想法,并进行了广泛的文献检索,为这封信奠定了基础。Ariful Haque博士协助最终审稿过程,并管理与期刊的通信,确保无缝沟通并符合提交要求。作者没有什么可报告的。作者没有什么可报告的。作者声明无利益冲突。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Addiction Biology
Addiction Biology 生物-生化与分子生物学
CiteScore
8.10
自引率
2.90%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Addiction Biology is focused on neuroscience contributions and it aims to advance our understanding of the action of drugs of abuse and addictive processes. Papers are accepted in both animal experimentation or clinical research. The content is geared towards behavioral, molecular, genetic, biochemical, neuro-biological and pharmacology aspects of these fields. Addiction Biology includes peer-reviewed original research reports and reviews. Addiction Biology is published on behalf of the Society for the Study of Addiction to Alcohol and other Drugs (SSA). Members of the Society for the Study of Addiction receive the Journal as part of their annual membership subscription.
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