Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms.

IF 3.9 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2025-01-19 DOI:10.5498/wjp.v15.i1.100880

Qi-Hui Jiang, Wei-Dong Gong

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Abstract

Background: The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia, especially thyroid hormones.

Aim: To study the relationship between triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH) and schizophrenia.

Methods: In this study, 100 schizophrenia patients were selected from our hospital between April 2022 and April 2024. Their clinical data were analyzed retrospectively. Based on the Positive and Negative Syndrome Scale (PANSS) score, patients were divided into mild (1-3 points, n = 39), moderate (4 points, n = 45), and severe groups (5-7 points, n = 16). Additionally, 55 healthy individuals served as a control group. Venous blood samples were collected to measure T3, T4, FT3, FT4, TSH, and cortisol concentrations, analyzing their relationship with PANSS scores.

Results: The serum levels of T3, FT3, FT4, TSH and cortisol in the schizophrenia group were lower than those in the control group (P < 0.05). With the increase of the severity of the disease, the concentrations of T3 and T4 decreased, while the concentrations of TSH and cortisol increased (P < 0.05). The concentrations of TSH and cortisol were positively correlated with the PANSS score, while T3 and T4 were negatively correlated with the PANSS score (P < 0.05). The receiver operating characteristic curve results showed that T3, T4, TSH, and cortisol had good efficacy in the diagnosis of schizophrenia. Logistic results showed that decreased T3 level, decreased T4 level, decreased TSH level and increased cortisol level may be independent risk factors for schizophrenia.

Conclusion: Thyroid hormone levels are associated with the severity of schizophrenia symptoms, which can provide new solutions for the diagnosis and treatment of schizophrenia.

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甲状腺激素水平与精神分裂症症状严重程度的相关性分析。

背景：体内激素水平失衡与精神分裂症的发生和发展密切相关，尤其是甲状腺激素。目的：探讨三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离T3 （FT3）、游离T4 （FT4）、促甲状腺激素（TSH）与精神分裂症的关系。方法：选取2022年4月至2024年4月我院收治的精神分裂症患者100例。回顾性分析其临床资料。根据PANSS （Positive and Negative Syndrome Scale）评分分为轻度组（1-3分，n = 39）、中度组（4分，n = 45）、重度组（5-7分，n = 16）。另外，55名健康个体作为对照组。采集静脉血，测定T3、T4、FT3、FT4、TSH、皮质醇浓度，分析其与PANSS评分的关系。结果：精神分裂症组血清T3、FT3、FT4、TSH、皮质醇水平均低于对照组（P < 0.05）。随着病情加重，T3、T4浓度降低，TSH、皮质醇浓度升高（P < 0.05）。TSH、皮质醇浓度与PANSS评分呈正相关，T3、T4与PANSS评分呈负相关（P < 0.05）。受试者工作特征曲线结果显示，T3、T4、TSH、皮质醇对精神分裂症的诊断有较好的疗效。Logistic分析结果显示，T3水平降低、T4水平降低、TSH水平降低、皮质醇水平升高可能是精神分裂症的独立危险因素。结论：甲状腺激素水平与精神分裂症症状严重程度相关，可为精神分裂症的诊断和治疗提供新的解决方案。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.