Analysis of the Clinicopathological Characteristics, Genetic Phenotypes, and Prognostics of Primary Pulmonary and Bronchial Adenoid Cystic Carcinoma.

IF 2.3 3区医学 Q3 ONCOLOGY

Thoracic Cancer Pub Date : 2025-01-01 DOI:10.1111/1759-7714.15526

Zhengyang Hu, Xing Jin, Jian Wang, Qihai Sui, Yanjun Yi, Dejun Zeng, Zhencong Chen, Qun Wang, Jiacheng Yin, Lin Wang, Zongwu Lin

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引用次数: 0

Abstract

Background: Primary pulmonary and bronchial adenoid cystic carcinoma (PACC) is a rare, low-grade malignant tumor of the lung. However, the relationship between its clinical features, surgical prognosis, and genetic phenotype has not been fully described.

Methods: PACC patient information was collected from the SEER, TCGA, and Zhongshan Hospital, Fudan University (FDZSH) databases. Overall survival (OS) was evaluated using the Kaplan-Meier method. Univariate and multivariate analyses through Cox proportional hazards regression identified risk factors that predicted OS. The limma and matfools packages from R were used to compare the differential genes and mutations between PACC and LUAD, respectively.

Results: Two hundred and ninety-two patients, 14 patients, and 12 patients with PACC were identified from the SEER, TCGA, and FDZSH databases, respectively. The 3-, 5-, and 10-year OS of the PACC patients were 91.7%, 88.6%, and 85.0%, respectively, compared to 95.8%, 93.9%, and 93.3% for patients who underwent surgery. Race, pathological grade, M stage, regional node examination, and regional node positive were independent prognostic factors for the OS of patients who underwent surgery. The gene map of PACC and lung adenocarcinoma (LUAD) shows significant differences. Common mutations found in lung cancer were almost undetectable in PACC patients, whereas mutations in the NOTCH pathway were more common. TMB levels and PD-1/PD-L1 expressions were also lower in PACC patients.

Conclusion: Our study analyzed the main factors that influence the prognosis of PACC patients undergoing surgery and discovered the unique genetic phenotype of PACC.

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原发性肺和支气管腺样囊性癌的临床病理特征、遗传表型和预后分析。

背景：原发性肺及支气管腺样囊性癌（PACC）是一种罕见的肺部低级别恶性肿瘤。然而，其临床特征、手术预后和遗传表型之间的关系尚未得到充分的描述。方法：PACC患者资料收集自SEER、TCGA和复旦大学中山医院（FDZSH）数据库。采用Kaplan-Meier法评估总生存期（OS）。通过Cox比例风险回归进行单因素和多因素分析，确定了预测OS的危险因素。使用R的limma和matfools软件包分别比较PACC和LUAD之间的差异基因和突变。结果：从SEER、TCGA和FDZSH数据库中分别鉴定出192例、14例和12例PACC患者。PACC患者的3年、5年和10年OS分别为91.7%、88.6%和85.0%，而手术患者的OS分别为95.8%、93.9%和93.3%。种族、病理分级、M分期、区域淋巴结检查、区域淋巴结阳性是影响手术患者OS的独立预后因素。PACC与肺腺癌（LUAD）的基因图谱存在显著差异。在肺癌中发现的常见突变在PACC患者中几乎检测不到，而NOTCH通路的突变更为常见。PACC患者TMB水平和PD-1/PD-L1表达也较低。结论：本研究分析了影响PACC手术患者预后的主要因素，发现了PACC独特的遗传表型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM

CiteScore

5.20

自引率

3.40%

发文量

439

审稿时长

2 months

期刊介绍： Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.