Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-01-02 DOI:10.1167/tvst.14.1.18

Guocheng Xiao, Mei Ge, Guoqing Qiao, Shuyu Liu, Na Li, Feng Liu, Yanye Lu, Qiushi Ren, Liqiang Wang

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引用次数: 0

Abstract

Purpose: The purpose of this study was to evaluate the correlation between axial length (AL) and retinal oxygen dynamic parameters in adult patients.

Methods: This was an observational cross-sectional study with 79 Chinese adults with myopia aged 18 to 37 years. All participants underwent AL measurements, cycloplegic refraction, and other ophthalmic examinations. Additionally, the retinal oxygen kinetics imaging and analysis (ROKIA) system was utilized to obtain the retinal oxygen dynamic parameters of all patients. Simple and multiple linear regression tests were used to assess the correlation between various oxygen dynamic parameters and AL.

Results: The mean age, AL, and spherical equivalent (SE) of subjects were 26.32 ± 5.4 years, 25.78 ± 1.06 mm, and -5.13 ± 2.1 diopters (D), respectively. The Pearson correlation coefficients among AL and retinal oxygen delivery (DO2) and retinal oxygen metabolism (MO2) were -0.44 (95% confidence interval = -0.24 to -0.60, P < 0.001), -0.26 (95% confidence interval = -0.04 to -0.46, P = 0.02), respectively. The group with high myopia exhibited lower DO2 and higher oxygen extraction fraction (OEF) compared with the group with moderate myopia, and no significant difference was observed in MO2 between the two groups. In multivariate analyses adjusting for age, sex, intraocular pressure (IOP), and anterior chamber depth (ACD), a longer AL was significantly associated with decreased DO2 (standardized regression coefficient B = -0.47, P < 0.001).

Conclusions: Retinal oxygen dynamic parameters, including DO2 and MO2, were decreased with longer AL in myopic eyes. Patients with high myopia demonstrated an elevated OEF than those with moderate myopia.

Translational relevance: This study demonstrated that the retinal oxygen metabolism changes in myopia, as confirmed using a novel device that quantifies retinal oxygen dynamic parameters and provides a new monitoring approach for other hypoxic retinal diseases.

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成人近视视轴长度与视网膜氧动力学的关系。

目的：本研究的目的是评估成人患者眼轴长（AL）与视网膜氧动力学参数的相关性。方法：对79例18 ~ 37岁近视成人进行观察性横断面研究。所有参与者都进行了AL测量、睫状体麻痹性屈光和其他眼科检查。此外，利用视网膜氧动力学成像与分析（ROKIA）系统获得所有患者的视网膜氧动力学参数。结果：受试者的平均年龄为26.32±5.4岁，AL为25.78±1.06 mm，球体等效（SE）为-5.13±2.1屈光度(D)。AL与视网膜氧输送（DO2）、视网膜氧代谢（MO2）的Pearson相关系数分别为-0.44（95%可信区间= -0.24 ~ -0.60,P < 0.001）、-0.26（95%可信区间= -0.04 ~ -0.46,P = 0.02）。高度近视组的DO2低于中度近视组，氧提取分数（OEF）高于中度近视组，MO2差异无统计学意义。在调整年龄、性别、眼内压（IOP）和前房深度（ACD）的多变量分析中，AL较长与DO2降低显著相关（标准化回归系数B = -0.47, P < 0.001）。结论：近视眼视网膜氧动力学参数DO2、MO2随AL延长而降低。高度近视患者的OEF高于中度近视患者。翻译相关性：本研究证实了近视视网膜氧代谢的变化，并使用一种新的设备量化视网膜氧动态参数，为其他缺氧性视网膜疾病提供了一种新的监测方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.