New insights into reductive stress responses and its clinical relation in cancer

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-01-10 DOI:10.1016/j.tice.2025.102736

Suman Kumar Ray , Sukhes Mukherjee

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引用次数: 0

Abstract

Cells are susceptible to both oxidative and reductive stresses, with reductive stress being less studied and potentially therapeutic in cancer. Reductive stress, characterized by an excess of reducing equivalents exceeding the activity of endogenous oxidoreductases, can lead to an imbalance in homeostasis, causing an increase in reactive oxygen species induction, affecting cellular antioxidant load and flux. Unlike oxidative stress, reductive stress has been understudied and poorly understood, and there is still much to learn about its mechanisms in cancer, its therapeutic potential, and how cancer cells react to it. Changes in redox balance and interference with redox signaling are linked to cancer cell growth, metastasis, and resistance to chemotherapy and radiation. Overconsumption of reducing equivalents can reduce metabolism, alter protein disulfide bond formation, disrupt mitochondrial homeostasis, and disrupt cancer cell signaling pathways. Novel approaches to delivering or using cancer medicines and techniques to influence redox biology have been discovered. Under reductive stress, cancer cells may coordinate separate pools of redox pairs, potentially impacting biology.

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肿瘤中还原性应激反应及其临床关系的新认识。

细胞对氧化应激和还原性应激都很敏感，对还原性应激的研究较少，但对癌症有潜在的治疗作用。还原性应激的特征是还原性当量的过量超过内源性氧化还原酶的活性，可导致体内平衡失衡，导致活性氧诱导增加，影响细胞抗氧化负荷和通量。与氧化应激不同，我们对还原性应激的研究还不够充分，对其在癌症中的作用机制、治疗潜力以及癌细胞对其的反应还有很多需要了解。氧化还原平衡的改变和对氧化还原信号的干扰与癌细胞的生长、转移以及对化疗和放疗的抵抗有关。过度消耗还原性等同物可以降低代谢，改变蛋白质二硫键的形成，破坏线粒体稳态，破坏癌细胞信号通路。已经发现了递送或使用癌症药物和技术来影响氧化还原生物学的新方法。在还原性应激下，癌细胞可能协调单独的氧化还原对池，潜在地影响生物学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.