Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects.

Abstract

Air pollution is increasingly recognized as a significant health risk, yet our understanding of its underlying chemical and physiological mechanisms remains incomplete. Fine particulate matter (PM_2.5) and ozone (O₃) interact with biomolecules in intracellular and microenvironments, such as the epithelial lining fluid (ELF), leading to the generation of reactive oxygen species (ROS). These ROS trigger cellular inflammatory responses and oxidative stress, contributing to a spectrum of diseases affecting the respiratory, cardiovascular, and central nervous systems. Extensive epidemiological and toxicological research highlights the pivotal role of ROS in air pollution-related diseases. It is crucial to comprehend the intricate chemical processes and accompanying physiological effects of ROS from air pollutants. This review aims to systematically summarize ROS generation mechanisms in the ELF and measurement techniques of oxidative potential (OP), taking the kinetic reactions of ROS cycling in the ELF as an example, and discusses the general health implications of ROS in respiratory, cardiovascular, and central nervous systems. Understanding these processes through interdisciplinary research is essential to develop effective and precise strategies as well as air quality standards to mitigate the public health impacts of air pollution globally.