Actinomycetes studies in Tunisia.

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Research in microbiology Pub Date : 2025-01-17 DOI:10.1016/j.resmic.2025.104279

Souleima Dhahbi, Jeonghee Lee, Dohee Ryu, Ganiyu Akinniyi, Inho Yang

引用次数: 0

Abstract

Tunisia, located in North Africa, has a diverse topography along the Mediterranean Sea to the Sahara Desert. These environments encompass oases, rhizosphere soils, desert deposits, saline wetlands, offshore oilrigs, and ancient monument rocks. The country's varied environments have led to the isolation of a multitude of actinomycetes. A phylogenetic analysis based on the 16S rRNA sequences of one hundred isolated actinomycetes strains revealed that the majority belong to the genus Streptomyces. Secondary metabolite studies from these actinomycetes yielded 33 natural products. Notably, compound 12, 3-O-methylviridicatin, exhibited antitumor activity and suppressed HIV expression. This showcases Tunisia's potential for natural product research.

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突尼斯放线菌研究。

突尼斯位于北非，从地中海到撒哈拉沙漠，地形多样。这些环境包括绿洲、根际土壤、沙漠沉积物、含盐湿地、海上石油钻井平台和古代纪念碑岩石。该国多变的环境导致了大量放线菌的分离。通过对100株分离的放线菌的16S rRNA序列进行系统发育分析，发现大多数放线菌属于链霉菌属。这些放线菌的次生代谢物研究产生了33种天然产物。值得注意的是，化合物12,3 - o -甲基vi可笑蛋白具有抗肿瘤活性并抑制HIV的表达。这显示了突尼斯在天然产品研究方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.