Stimulate to Remember? The Effects of Short Burst of Transcutaneous Vagus Nerve Stimulation (taVNS) on Memory Performance and Pupil Dilation.

IF 2.9 2区心理学 Q2 NEUROSCIENCES

Psychophysiology Pub Date : 2025-01-01 DOI:10.1111/psyp.14753

Mareike Ludwig, Matthew J Betts, Dorothea Hämmerer

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引用次数: 0

Abstract

The decline in noradrenergic (NE) locus coeruleus (LC) function in aging is thought to be implicated in episodic memory decline. Transcutaneous auricular vagus nerve stimulation (taVNS), which supports LC function, might serve to preserve or improve memory function in aging. However, taVNS effects are generally very heterogeneous, and it is currently unclear whether taVNS has an effect on memory. In this study, an emotional memory task with negative events involving the LC-NE system was combined with the short burst of event-related taVNS (3 s) in younger adults (N = 24). The aim was to investigate taVNS-induced changes in pupil dilation during encoding and possible taVNS-induced improvements in (emotional) memory performance for early and delayed (24 h) recognition. Negative events were associated with increased pupil dilation and better memory performance. Additionally, real as compared to sham or no stimulation selectively increased memory for negative events. Short bursts of stimulation, whether real or sham, led to an increase in pupil dilation and an improvement in memory performance over time, likely due to the attention-inducing sensory modulation of electrical stimulation.

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刺激记忆？经皮迷走神经短脉冲刺激（taVNS）对记忆和瞳孔扩张的影响。

去肾上腺素能（NE）蓝斑（LC）功能在衰老过程中的下降被认为与情景记忆衰退有关。经皮耳迷走神经刺激（taVNS）支持LC功能，可能具有保护或改善衰老记忆功能的作用。然而，taVNS的作用通常是非常不均匀的，目前尚不清楚taVNS是否对记忆有影响。在本研究中，青年人（N = 24）将一项涉及LC-NE系统的负面事件的情绪记忆任务与事件相关taVNS短爆发（3秒）相结合。目的是研究tavns诱导的编码过程中瞳孔扩张的变化，以及tavns诱导的早期和延迟（24小时）识别（情绪）记忆表现的可能改善。消极事件与瞳孔扩大和更好的记忆表现有关。此外，与假刺激或无刺激相比，真实刺激选择性地增加了对负面事件的记忆。短时间的刺激，无论是真实的还是虚假的，都会导致瞳孔扩张的增加和随着时间的推移记忆力的提高，这可能是由于电刺激引起的注意力诱导的感官调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychophysiology 医学-神经科学

CiteScore

6.80

自引率

8.10%

发文量

225

审稿时长

2 months

期刊介绍： Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.