Polyethylene Glycol microspheres for uterine artery embolization for the treatment of symptomatic uterine fibroids.

IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Floriana Nardelli, Fernanda Ciferri, Pierluigi Muratore, Federica Fumarola, Riccardo Faletti, Maria Antonella Ruffino, Marco Calandri, Valeria Accortanzo, Paolo Cortese, Andrea Discalzi
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Abstract

Background: Uterine fibroids are prevalent benign pelvic tumors, often causing debilitating symptoms that impair quality of life. Uterine fibroid embolization (UFE) is a consolidated minimally invasive treatment option. The purpose of this study is to report our experience with polyethylene glycol microspheres (HydroPearl) in UFE for symptomatic patients.

Methods: This single-center retrospective study evaluated 37 consecutive patients with symptomatic uterine fibroids referred to our institution since November 2016 to February 2020 for UFE with HydroPearl microspheres. All patients included completed a comprehensive pre-UFE clinical assessment and underwent a magnetic resonance imaging (MRI) pre- and post-procedure. Technical success, procedure-related complications, clinical outcomes, follow-up MRI findings, and patient satisfaction were evaluated.

Results: A technical success rate of 97% with complete bilateral uterine artery embolization was achieved. Significant improvements were observed in menorrhagia, bulk-type symptoms, abdominal pain, and urinary dysfunctions after UFE. Post-procedural MRI assessments demonstrated reductions in uterine and dominant fibroid volumes, indicating successful devascularization. No immediate procedural complications were reported. Symptoms interfering with everyday activities significantly improved after the procedure. Patient satisfaction was high, with 89% expressing satisfaction with the treatment and 84% indicating purpose to repeat the procedure if necessary.

Conclusions: Uterine artery embolization with HydroPearl is a safe and effective treatment option for symptomatic uterine fibroids. A significant improvement in menorrhagia and bulk-type symptoms after the procedure was observed correlated by a reduction in diameters and volumes of both the uterus and the main fibroid in post-procedural MRI.

聚乙二醇微球用于子宫动脉栓塞治疗症状性子宫肌瘤。
背景:子宫肌瘤是常见的盆腔良性肿瘤,常引起衰弱症状,影响生活质量。子宫肌瘤栓塞术(UFE)是一种巩固的微创治疗选择。本研究的目的是报告我们使用聚乙二醇微球(HydroPearl)治疗有症状的UFE患者的经验。方法:本研究为单中心回顾性研究,对2016年11月至2020年2月在我院连续就诊的37例有症状的子宫肌瘤患者进行HydroPearl微球UFE治疗。所有患者均完成了全面的ufe术前临床评估,并在术前和术后进行了磁共振成像(MRI)检查。评估技术成功、手术相关并发症、临床结果、随访MRI结果和患者满意度。结果:双侧子宫动脉完全栓塞术技术成功率达97%。UFE术后月经过多、体积型症状、腹痛和尿功能障碍均有显著改善。术后MRI评估显示子宫和主要肌瘤体积减少,表明成功断流。没有立即的手术并发症报告。手术后干扰日常活动的症状明显改善。患者满意度很高,89%的患者对治疗表示满意,84%的患者表示必要时可以重复治疗。结论:对有症状的子宫肌瘤进行子宫动脉栓塞是一种安全有效的治疗方法。手术后子宫和主要肌瘤的直径和体积减小与手术后子宫和主要肌瘤的直径和体积减小相关,观察到月经过多和体积型症状的显著改善。
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来源期刊
Radiologia Medica
Radiologia Medica 医学-核医学
CiteScore
14.10
自引率
7.90%
发文量
133
审稿时长
4-8 weeks
期刊介绍: Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.
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