Prior knowledge changes initial sensory processing in the human spinal cord

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-01-15 DOI:10.1126/sciadv.adl5602

Max-Philipp Stenner, Cindy Márquez Nossa, Tino Zaehle, Elena Azañón, Hans-Jochen Heinze, Matthias Deliano, Lars Büntjen

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Abstract

Prior knowledge changes how the brain processes sensory input. Whether knowledge influences initial sensory processing upstream of the brain, in the spinal cord, is unknown. Studying electric potentials recorded invasively and noninvasively from the human spinal cord at millisecond resolution, we find that the cord generates electric potentials at 600 hertz that are modulated by prior knowledge about the time of sensory input, as early as 13 to 16 milliseconds after stimulation. Our results reveal that already in the spinal cord, sensory processing is under top-down, cognitive control, and that 600-hertz signals, which have been identified as a macroscopic marker of population spiking in other regions of the nervous system, play a role in early, context-dependent sensory processing. The possibility to examine these signals noninvasively in humans opens up avenues for research into the physiology of the spinal cord and its interaction with the brain.

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先验知识改变了人类脊髓的初始感觉处理。

先前的知识改变了大脑处理感觉输入的方式。知识是否会影响大脑上游，即脊髓的初始感觉处理，目前尚不清楚。研究以毫秒分辨率记录的人类脊髓有创和无创电位，我们发现脊髓产生600赫兹的电势，这种电势是由感官输入时间的先验知识调制的，早在刺激后13至16毫秒。我们的研究结果表明，在脊髓中，感觉加工已经受到自上而下的认知控制，并且600赫兹信号已经被确定为神经系统其他区域人口峰值的宏观标记，在早期的，情境依赖的感觉加工中发挥作用。在人体中无创检测这些信号的可能性，为研究脊髓生理学及其与大脑的相互作用开辟了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.