Paternal Cyanidin-3-O-Glucoside Diet Improved High-Fat, High-Fructose Diet-Induced Intergenerational Inheritance in Male Offspring's Susceptibility to High-Fat Diet-Induced Testicular and Sperm Damage.

IF 2.6 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Yuxi Li, Liwang Liu, Yulin Zhang, Shun Bai, Yan Jiang, Caiyong Lai, Xusheng Li, Weibin Bai
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Abstract

High-fructose and high-fat diet (HFHFD) has been associated with impaired spermatogenesis, leading to decreased sperm quality and increased male infertility, with similar effects observed in offspring. Cyanidin-3-O-glucoside (C3G), a recognized food antioxidant, has shown promise in protecting in male reproduction and modulating epigenetic modifications. However, its potential role in ameliorating intergenerational inheritance induced by HFHFD remains underexplored. In this study, we investigated the effects of paternal HFHFD on reproductive injury of offspring and the protective effect of C3G. Paternal mice were subjected to 12 weeks of HFHFD induction and C3G treatment was conducted for 8 weeks. Offspring obtained via in vitro fertilization were fed either a normal diet (ND) or high-fat diet (HFD). Our findings indicate that while the paternal HFHFD did not result in observable reproductive impairments in paternal mice, it did affect offspring testicular function through intergenerational inheritance, rendering them more susceptible to testicular damage and reduced sperm counts when exposed to an HFD. Notably, C3G intervention significantly mitigated these effects, suggesting its potential as a therapeutic compound for alleviating the impact of paternal intergenerational inheritance on male fertility resulting from HFHFD. These results underscore the importance of further exploring the mechanisms underlying intergenerational inheritance and the potential of interventions such as C3G in mitigating its effects, with implications for both basic research and clinical practice.

父亲的花青素-3- o -葡萄糖苷饮食改善了高脂肪、高果糖饮食诱导的雄性后代对高脂肪饮食诱导的睾丸和精子损伤易感性的代际遗传。
高果糖和高脂肪饮食(HFHFD)与精子发生受损有关,导致精子质量下降和男性不育增加,在后代中也观察到类似的影响。花青素-3- o -葡萄糖苷(C3G)是一种公认的食品抗氧化剂,在保护男性生殖和调节表观遗传修饰方面显示出前景。然而,其在改善HFHFD诱导的代际遗传中的潜在作用仍未得到充分探讨。本研究探讨了父本HFHFD对子代生殖损伤的影响及C3G的保护作用。父本小鼠经HFHFD诱导12周,C3G治疗8周。通过体外受精获得的后代分别饲喂正常饮食(ND)和高脂肪饮食(HFD)。我们的研究结果表明,虽然父亲的HFHFD没有导致父亲小鼠的可观察到的生殖损伤,但它确实通过代际遗传影响后代的睾丸功能,使它们更容易受到睾丸损伤和精子数量减少。值得注意的是,C3G干预显著减轻了这些影响,这表明它有可能作为一种治疗化合物,减轻父亲代际遗传对HFHFD导致的男性生育能力的影响。这些结果强调了进一步探索代际遗传机制的重要性,以及C3G等干预措施在减轻其影响方面的潜力,这对基础研究和临床实践都有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reproductive Sciences
Reproductive Sciences 医学-妇产科学
CiteScore
5.50
自引率
3.40%
发文量
322
审稿时长
4-8 weeks
期刊介绍: Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
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