The roles of cannabis potency and gender in cannabis dependence and anxiety in recent cannabis users with trauma exposure histories

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2025-02-01 DOI:10.1016/j.phrs.2025.107586

T. Snooks , S.H. Stewart , P. Romero-Sanchiz , S. DeGrace , S.P. Barrett , H.C.R. Bernusky , P.G. Tibbo

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引用次数: 0

Abstract

Over the past 20 years, levels of Δ9-tetrahydrocannabinol (THC) in cannabis have significantly increased, while levels of cannabidiol (CBD) have increased much less in comparison. Cannabis with higher THC potency (commonly assessed via THC:CBD ratio) may increase the risk for cannabis dependence and trigger/exacerbate anxiety. However, few studies of cannabis potency effects on cannabis dependence and anxiety have examined gender moderation. Additionally, there are issues with how cannabis potency is calculated via the THC:CBD ratio that may contribute to inconsistencies in the literature. N = 202 (55.8 % women) recent cannabis users (>1 g in the past month) with trauma histories – a group at high risk for anxiety and cannabis dependence – completed an online survey including a self-report measure of THC and CBD levels in participants’ typically-used cannabis product. Cannabis potency was calculated as THC:CBD ratio (THC%/CBD%) and as relative THC proportion (THC%/[THC%+CBD%]). Cannabis dependence and anxiety levels were self-reported on the Cannabis Use Disorder Identification Test-Revised (CUDIT-R) and Generalized Anxiety Disorder-7 (GAD-7), respectively. Consistent with prior findings in the general population, cannabis potency was significantly positively correlated with cannabis dependence, p = .002, and anxiety levels, p = .020, but only when assessed via THC proportion and not THC:CBD ratio. Consistent with prior research, women reported significantly higher anxiety levels but also unexpectedly, higher THC:CBD ratios, than men. No significant gender differences were found in the associations of either potency measure with either outcome variable. Results are consistent with recent reports of gender convergence in cannabis use prevalence. Additionally, these results identify relative THC proportion as a superior predictor of adverse cannabis and anxiety outcomes than the THC:CBD ratio in both men and women.

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大麻效价和性别在近期有创伤暴露史的大麻使用者大麻依赖和焦虑中的作用。

在过去的20年里，大麻中Δ9-tetrahydrocannabinol （THC）的含量显著增加，而大麻二酚（CBD）的含量相比之下增加得少得多。四氢大麻酚效价较高的大麻（通常通过四氢大麻酚：CBD的比例来评估）可能会增加大麻依赖的风险，引发/加剧焦虑。然而，很少有关于大麻效力对大麻依赖和焦虑的影响的研究审查了性别节制。此外，如何通过THC:CBD的比例来计算大麻的效力也存在问题，这可能会导致文献中的不一致。N = 202（55.8%为女性）最近有创伤史的大麻使用者（过去一个月有110克）——这是一个焦虑和大麻依赖的高风险群体——完成了一项在线调查，其中包括参与者通常使用的大麻产品中四氢大麻酚和CBD水平的自我报告。大麻效价计算为THC:CBD比（THC%/CBD%）和THC相对比（THC%/[THC%+CBD%]）。大麻依赖和焦虑水平分别在大麻使用障碍识别测试（CUDIT-R）和广泛性焦虑障碍-7 （GAD-7）中自我报告。与先前在一般人群中的发现一致，大麻效力与大麻依赖显著正相关，p =。002，焦虑水平，p =。020，但仅以THC比例评估，而不以THC:CBD比例评估。与之前的研究一致，女性报告的焦虑水平明显高于男性，但出乎意料的是，四氢大麻酚：CBD的比例也高于男性。在两种效价测量与两种结果变量的关联中，没有发现显著的性别差异。结果与最近关于大麻使用率性别趋同的报告相一致。此外，这些结果表明，在男性和女性中，THC的相对比例比THC:CBD的比例更能预测大麻和焦虑的不良后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.