Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI:10.1515/med-2024-1114

QiuMin Zhao, ShiYan Ji, HaiPing Jiang, DongMing Lu, LiFen Qian, JingWen Zhang, Yue Cui, Wei Lin, HaoYing Ge, Meng Gu

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引用次数: 0

Abstract

Objective: This study investigated the clinical significance of plasma sB7-H3 and YKL-40 levels in children with refractory Mycoplasma pneumoniae pneumonia (RMPP).

Methods: A total of 182 RMPP patients (103 general Mycoplasma pneumoniae patients and 79 RMPP patients) were included. sB7-H3, YKL-40, and other inflammatory factors were measured. Independent factors associated with the early diagnosis of RMPP were determined. The value of each independent risk factor in predicting RMPP was evaluated.

Results: The RMPP group reported significantly longer hospital stays and total fever durations. Levels of C-reactive protein, D-dimer, IL-13, IL-6/-10, sB7-H3, and YKL-40 were higher in the RMPP group. sB7-H3 was positively correlated with IL-13, IL-6, and IL-4, whereas YKL-40 was positively correlated with all of the above indicators (IL-5 was also included). sB7-H3 and YKL-40 were independent risk factors for RMPP. The critical values for sB7-H3 and YKL-40 were 3.525 and 313.3 ng/mL, respectively. sB7-H3 and YKL-40 had areas under the curve of 0.734 and 0.859, respectively. YKL-40 had high sensitivity and specificity of 88.61 and 87.38%, respectively. Both indicators had predictive value, YKL-40 had the highest predictive ability for RMPP.

Conclusion: Detection of sB7-H3 and YKL-40 levels in the plasma may be useful in diagnosing RMPP early in the disease process.

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血浆sB7-H3和YKL-40对小儿难治性肺炎支原体肺炎的预测价值。

目的：探讨难治性肺炎支原体肺炎（RMPP）患儿血浆sB7-H3、YKL-40水平的临床意义。方法：182例RMPP患者，其中普通肺炎支原体患者103例，RMPP患者79例。检测sB7-H3、YKL-40等炎性因子。确定与RMPP早期诊断相关的独立因素。评估各独立危险因素在预测RMPP中的价值。结果：RMPP组的住院时间和总发热时间明显延长。RMPP组c反应蛋白、d -二聚体、IL-13、IL-6/-10、sB7-H3、YKL-40水平升高。sB7-H3与IL-13、IL-6、IL-4呈正相关，而YKL-40与上述指标均呈正相关（也包括IL-5）。sB7-H3和YKL-40是RMPP的独立危险因素。sB7-H3和YKL-40的临界值分别为3.525和313.3 ng/mL。sB7-H3和YKL-40的曲线下面积分别为0.734和0.859。YKL-40的敏感性和特异性分别为88.61%和87.38%。两项指标均有预测价值，其中YKL-40对RMPP的预测能力最高。结论：检测血浆中sB7-H3和YKL-40水平可能有助于RMPP的早期诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.