Disseminated TB With IRIS Presenting as a Pancreatic Mass in Newly Diagnosed HIV: A Case Report.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2024-12-21 eCollection Date: 2025-01-01 DOI:10.1093/ofid/ofae746

Nina Akbar, Peter Mariuz

引用次数: 0

Abstract

Pancreatic tuberculosis (TB) is an uncommon extrapulmonary presentation of TB. Identification of coinfection with HIV may unmask not only disseminated TB but also immune reconstitution inflammatory syndrome (IRIS). We present the case of a 70-year-old Indian woman newly diagnosed with AIDS and pancreatic tuberculosis with miliary disseminated disease. Her clinical course was complicated by IRIS related to HIV-TB coinfection despite sequential and targeted anti-infective therapies. We review the presentation, pathophysiology, and risk factors for developing IRIS with HIV and pancreatic TB.

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弥散性结核伴IRIS在新诊断的HIV中表现为胰腺肿块：1例报告。

胰腺结核是一种罕见的肺外结核表现。HIV合并感染的鉴定不仅可以揭示播散性结核，还可以揭示免疫重建炎症综合征（IRIS）。我们提出的情况下，70岁的印度妇女新诊断为艾滋病和胰腺结核与军事播散性疾病。尽管进行了顺序和靶向抗感染治疗，但她的临床过程仍因与HIV-TB合并感染相关的IRIS而复杂化。我们回顾了IRIS合并HIV和胰腺结核的表现、病理生理和危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.