Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-01-16 DOI:10.1016/j.neuroimage.2025.121029

Yuanyuan Gao , Ying Hu , Jinlian Wang , Chang Liu , Hohjin Im , Weipeng Jin , Wenwei Zhu , Wei Ge , Guang Zhao , Qiong Yao , Pinchun Wang , Manman Zhang , Xin Niu , Qinghua He , Qiang Wang

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引用次数: 0

Abstract

Short video addiction (SVA) has emerged as a growing behavioral and social issue, driven by the widespread use of digital platforms that provide highly engaging, personalized, and brief video content. We investigated the neuroanatomical and functional substrates of SVA symptoms, alongside brain transcriptomic and cellular characteristics, using Inter-Subject Representational Similarity Analysis (IS-RSA) and transcriptomic approaches. Behaviorally, we found that dispositional envy was associated with SVA. Structurally, SVA was positively correlated with increased morphological volumes in the orbitofrontal cortex (OFC) and bilateral cerebellum. Functionally, the dorsolateral prefrontal cortex (DLPFC), posterior cingulate cortex (PCC), cerebellum, and temporal pole (TP) exhibited heightened spontaneous activity, which was positively correlated with SVA severity. Transcriptomic and cellular analyses also showed specific genes linked to gray matter volume (GMV) associated with SVA, with predominant expression in excitatory and inhibitory neurons. These genes showed distinct spatiotemporal expression patterns in the cerebellum during adolescence. This study offers a comprehensive framework integrating structural, functional, and neurochemical evidence to highlight the neural-transcriptomic underpinnings of SVA symptoms in a non-clinical population.

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短视频成瘾的神经解剖学和功能基础及其与脑转录组学和细胞结构的关系。

短视频成瘾（SVA）已经成为一个日益严重的行为和社会问题，这是由数字平台的广泛使用推动的，这些平台提供了高度吸引人的、个性化的、简短的视频内容。我们研究了SVA症状的神经解剖学和功能基础，以及脑转录组学和细胞特征，使用主体间代表性相似性分析（IS-RSA）和转录组学方法。在行为上，我们发现性格上的嫉妒与SVA有关。在结构上，SVA与眶额皮质（OFC）和双侧小脑形态体积的增加呈正相关。在功能上，背外侧前额叶皮层（DLPFC）、后扣带皮层（PCC）、小脑和颞极（TP）表现出较高的自发活动，与SVA严重程度呈正相关。转录组学和细胞分析也显示了与SVA相关的灰质体积（GMV）相关的特定基因，主要表达在兴奋性和抑制性神经元中。这些基因在青春期的小脑中表现出不同的时空表达模式。本研究提供了一个综合结构、功能和神经化学证据的综合框架，以突出非临床人群中SVA症状的神经转录组学基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.