Pharmacodynamics of interspecies interactions in polymicrobial infections.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-01-21 DOI:10.1038/s41522-024-00621-6

C Herzberg, J G C van Hasselt

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Abstract

The pharmacodynamic response of bacterial pathogens to antibiotics can be influenced by interactions with other bacterial species in polymicrobial infections (PMIs). Understanding the complex eco-evolutionary dynamics of PMIs and their impact on antimicrobial treatment response represents a step towards developing improved treatment strategies for PMIs. Here, we investigated how interspecies interactions in a multi-species bacterial community affect the pharmacodynamic response to antimicrobial treatment. To this end, we developed an in silico model which combined agent-based modeling with ordinary differential equations. Our analyses suggest that both interspecies interactions, modifying either drug sensitivity or bacterial growth rate, and drug-specific pharmacological properties drive the bacterial pharmacodynamic response. Furthermore, lifestyle of the bacterial population and the range of interactions can influence the impact of species interactions. In conclusion, this study provides a foundation for the design of antimicrobial treatment strategies for PMIs which leverage the effects of interspecies interactions.

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多种微生物感染中种间相互作用的药效学研究。

在多微生物感染中，细菌病原体对抗生素的药效学反应可能受到与其他细菌物种相互作用的影响。了解PMIs复杂的生态进化动态及其对抗菌治疗反应的影响，是朝着开发改进PMIs治疗策略迈出的一步。在这里，我们研究了多物种细菌群落中的种间相互作用如何影响抗菌药物治疗的药效学反应。为此，我们开发了一个将基于智能体的建模与常微分方程相结合的计算机模型。我们的分析表明，种间相互作用，改变药物敏感性或细菌生长速度，以及药物特异性药理学性质驱动细菌的药效学反应。此外，细菌种群的生活方式和相互作用的范围可以影响物种相互作用的影响。总之，本研究为利用种间相互作用的PMIs抗菌治疗策略的设计提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.