Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study.

IF 3.7 2区医学 Q1 RHEUMATOLOGY

Lupus Science & Medicine Pub Date : 2025-01-19 DOI:10.1136/lupus-2024-001309

Veronika Balajková, Aneta Prokopcová, Martin Elisak, Hana Mojžišová, Karel Pavelka, Marta Olejárová

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引用次数: 0

Abstract

Background: The neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum as a marker of neuronal damage may be a potential biomarker of neuropsychiatric involvement in SLE (NPSLE).

Methods: 80 patients with SLE were included.We obtained paired serum and CSF samples from 48 patients (NPSLE n=32, non-NPSLE n=16) and 31 controls. The serum and CSF levels of NfL were determined using ELISA.

Results: Patients with NPSLE demonstrated significantly higher levels of serum NfL compared with the non-NPSLE group (mean 31.68±36.63 pg/mL vs mean 16.75±12.48 pg/mL, respectively, p<0.05) and with controls (mean 10.74±4.36 pg/mL, p<0.01). Notably, CSF NfL concentrations in patients with NPSLE showed an upward trend (mean 1600±2852 pg/mL) in contrast to non-NPSLE patients (mean 393.4±191.9 pg/mL) and controls (mean 509.7±358.5 pg/mL). Furthermore, a positive correlation was observed between serum and CSF NfL levels in patients with NPSLE (R=0.8686, p<0.01). Elevated serum triacylglycerol concentrations, C reactive protein and organ damage were linked to increased serum (p=0.002; p<0.001; p=0.036) and CSF (p=0.008; p=0.007; p<0.001) NfL concentrations. In addition, we established a significant correlation between intrathecal NfL concentrations and interleukin-6 levels in the CSF of patients with NPSLE (R=0.5118, p<0.05).

Conclusion: The serum NfL levels may be a readily available marker of neuropsychiatric involvement in SLE.

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神经精神系统红斑狼疮患者血清神经丝轻链水平升高：一项横断面研究。

背景：脑脊液（CSF）和血清中的神经丝轻链（NfL）作为神经元损伤的标志物可能是SLE （NPSLE）中神经精神参与的潜在生物标志物。方法：80例SLE患者。我们获得了48例患者（NPSLE患者32例，非NPSLE患者16例）和31例对照者的配对血清和脑脊液样本。采用ELISA法测定血清和脑脊液中NfL的水平。结果：NPSLE患者血清NfL水平明显高于非NPSLE组（平均31.68±36.63 pg/mL vs平均16.75±12.48 pg/mL）。结论：血清NfL水平可能是SLE神经精神损害的一个容易获得的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lupus Science & Medicine RHEUMATOLOGY-

CiteScore

5.30

自引率

7.70%

发文量

审稿时长

15 weeks

期刊介绍： Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.