Theoretical evaluation of the biological activity of hydrogen.

Abstract

Hydrogen (H2), the simplest and most ubiquitous molecule in the universe, has garnered significant scientific interest over the past two decades because of its potential as an effective antioxidant and anti-inflammatory agent. Traditionally considered inert, H2 is now being re-evaluated for its unique bioactive properties. H2 selectively neutralizes reactive oxygen and nitrogen species, mitigating oxidative stress without disrupting essential cellular functions. This review therefore aims to provide a theoretical evaluation of the biological activity of H2, focusing on its pharmacokinetics, including absorption, distribution, and retention within biological systems. The pharmacokinetic profile of H2 is crucial for understanding its potential therapeutic applications. The interaction of H2 with protein pockets is of particular interest, as these sites may serve as reservoirs or active sites for H2, influencing its biological activity and retention time. Additionally, the impact of H2 on cellular signaling pathways, including those regulating glucose metabolism and oxidative stress responses, will be explored, offering insights into its potential as a modulator of metabolic and redox homeostasis. Finally, interactions with ferromagnetic molecules within biological environments, as well as effects on cellular signaling mechanisms, add another layer of complexity to the biological role of H2. By synthesizing the current research, this review seeks to elucidate the underlying mechanisms by which H2 may exert therapeutic effects while also identifying critical areas for further investigation. Understanding these aspects is essential for fully characterizing the pharmacodynamic profile of H2 and assessing its clinical potential in the treatment of oxidative stress-related disorders.