CESTsimu: An open-source GUI for spectral and spatial CEST simulation.

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medicine Pub Date : 2025-01-20 DOI:10.1002/mrm.30430

Huabin Zhang, Bensheng Qiu, Jiadi Xu, Kannie Wy Chan, Jianpan Huang

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引用次数: 0

Abstract

Purpose: The aim of this study was to create a user-friendly CEST simulation tool with a GUI for both spectral (1D Z-spectra) and spatial (2D phantom) CEST experiments, making the CEST simulation easier to perform.

Methods: CESTsimu was developed using MATLAB App Designer. It consists of three modules: Saturation Settings, Exchange Settings, and Phantom Settings. CESTsimu can not only import/export files in the defined format but can also import files generated by other existing simulation platforms (e.g. pulseq-CEST).

Results: The 1D Z-spectrum simulation results demonstrated the effectiveness of CESTsimu in simulating Z-spectra under various saturation ( $B_{0}$ and $B_{1}$ ) and exchange settings (concentration and exchange rate). The 2D simulation results showed that CESTsimu can generate an arbitrary number of phantoms with different shapes under different noise conditions. Notably, CESTsimu could also simulate $B_{0}$ and $B_{1}$ inhomogeneity in 2D patterns that mimicked practical conditions. Moreover, the accuracy of CESTsimu was validated by simulating 8 cases in the BMsim challenge.

Conclusion: We developed a user-friendly CESTsimu GUI for intuitively simulating CEST experiments under diverse saturation and exchange settings in 1D and 2D conditions. CESTsimu has the potential to facilitate the broad utilization of CEST MRI among a wide range of users.

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CESTsimu：光谱和空间CEST模拟的开源GUI。

目的：本研究的目的是创建一个用户友好的CEST模拟工具，具有GUI，用于光谱（1D z光谱）和空间（2D幻影）CEST实验，使CEST模拟更容易执行。方法：采用MATLAB App Designer软件开发CESTsimu。它由三个模块组成：饱和度设置，交换设置和幻影设置。CESTsimu不仅可以导入/导出已定义格式的文件，还可以导入其他现有仿真平台（例如pulseq-CEST）生成的文件。结果：一维z谱模拟结果表明，CESTsimu在模拟不同饱和度（b0 $$ {\mathrm{B}}_0 $$和b1 $$ {\mathrm{B}}_1 $$）和交换设置（浓度和交换率）下的z谱是有效的。二维仿真结果表明，CESTsimu可以在不同噪声条件下生成任意数量的不同形状的幻影。值得注意的是，CESTsimu还可以在模拟实际条件的2D模式中模拟b0 $$ {\mathrm{B}}_0 $$和b1 $$ {\mathrm{B}}_1 $$的不均匀性。通过对BMsim挑战中8个案例的仿真，验证了CESTsimu的准确性。结论：我们开发了一个用户友好的CESTsimu GUI，可以直观地模拟一维和二维条件下不同饱和度和交换设置下的CEST实验。CESTsimu有潜力促进CEST MRI在广泛用户中的广泛应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.