Relationship between oxidative balance score and all-cause mortality in hypertension.

IF 1.8 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Research Pub Date : 2025-01-17 DOI:10.1159/000543471

Tianyi Ma, Ling Wang, Xiaorong Yan

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引用次数: 0

Abstract

Introduction: Exploring the association between oxidative balance score (OBS) and all-cause mortality in hypertension (HTN).

Methods: Data for HTN patients from 2007 to 2018 were extracted from the National Health and Nutrition Examination Survey (NHANES). OBS offers a thorough evaluation of an individual's redox status, with higher score indicates favorable oxidative homeostasis. All-cause mortality was obtained by linkage to National Death Index records through 31 December 2019. Weighted multivariable Cox regression models, Kaplan-Meier curves, receiver operator characteristic (ROC) curve, and random survival forests (RSF) analysis were applied to examine the relationship between OBS and all-cause mortality in HTN.

Results: The cohort included 13,130 participants, with 2,132 deaths. Higher OBS was associated with lower all-cause mortality risk (HR=0.77, 95%CI: 0.65-0.91) in HTN. The relationship also existed in subgroups of male, having/haven't chronic kidney disease, and having cardiovascular disease. Kaplan-Meier curves suggested that participants with higher OBS had superior survival rates compared to those with lower intake. The RSF showed a better survival predictive role for physical activity among the components of OBS.

Conclusion: Higher OBS was related to lower odds of all-cause mortality in patients with HTN. Adopting a healthy lifestyle and consuming an antioxidant-rich diet may improve the prognosis of patients with HTN.

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高血压患者氧化平衡评分与全因死亡率的关系。

前言：探讨氧化平衡评分（OBS）与高血压（HTN）全因死亡率之间的关系。方法：从国家健康与营养检查调查（NHANES）中提取2007 - 2018年HTN患者的数据。OBS对个体氧化还原状态进行全面评估，分数越高表明氧化稳态越好。通过与截至2019年12月31日的国家死亡指数记录联系获得全因死亡率。采用加权多变量Cox回归模型、Kaplan-Meier曲线、receiver operator characteristic （ROC）曲线和随机生存森林（RSF）分析，探讨HTN患者OBS与全因死亡率的关系。结果：该队列包括13130名参与者，其中2132人死亡。高OBS与HTN患者低全因死亡风险相关（HR=0.77, 95%CI: 0.65-0.91）。这种关系也存在于男性、有/没有慢性肾脏疾病和有心血管疾病的亚组中。Kaplan-Meier曲线表明，OBS较高的参与者比摄入量较低的参与者生存率更高。在OBS的组成部分中，RSF对身体活动有更好的生存预测作用。结论：高OBS与HTN患者低全因死亡率相关。采用健康的生活方式和食用富含抗氧化剂的饮食可改善HTN患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Research 医学-生理学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.