Exercise as a mediator between childhood adversity and psychological distress: Can BDNF moderate the mediating effect?

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-01-10 DOI:10.1016/j.jpsychires.2025.01.017

Jia Chi Chan, Chih-Ting Lee, Yee-How Say, Yu-Fang Lin, Meng-Che Tsai

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引用次数: 0

Abstract

Background: Adverse childhood events (ACEs) have been associated with an increased risk of psychiatric disorders in young adulthood. To identify at-risk individuals and potential strategies to combat the negative impacts of ACE, this study investigated the mediating role of exercise in the relationship between psychological distress and ACEs. Further, we examined the moderating effect of the BDNF polymorphism in the mediation relationship.

Methods: Participants (N = 750, Mage = 20.1 years) completed questionnaires assessing ACEs divided into adverse environment (AE) and childhood maltreatment (CM), exercise, and psychological distress. Salivary genomic DNA was used for genotyping. The significance of the moderated mediation model was assessed using bootstrapping.

Results: There was a significant association between ACEs and psychological distress mediated by exercise. After addition of BDNF polymorphism, we found that the effect of ACEs on psychological distress through exercise was moderated by the BDNF polymorphism (index of moderated mediation = -0.19, [-0.48, -0.04], p-value ≤0.05). Further dividing ACE into AE and CM, the moderated mediation relationship remains significant only with AE (index of moderated mediation = -0.41, [-0.99, -0.10], p-value ≤0.05).

Conclusions: The interaction between BDNF polymorphism and exercise may be a suitable target for interventions in ACEs-experienced individuals for the prevention or reduction of psychological distress.

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运动在童年逆境和心理困扰之间的中介作用：BDNF能否调节其中介作用？

背景：童年不良事件（ace）与成年早期精神疾病的风险增加有关。为了确定ACE的高危人群和潜在的应对策略，本研究探讨了运动在心理困扰和ACE之间的中介作用。进一步，我们研究了BDNF多态性在中介关系中的调节作用。方法：参与者（N = 750，年龄20.1岁）完成不良环境（AE）和童年虐待（CM）、运动和心理困扰等方面的不良经历评估问卷。唾液基因组DNA进行基因分型。采用自举法评估被调节中介模型的显著性。结果：ace与运动引起的心理困扰有显著相关。在加入BDNF多态性后，我们发现ace对运动心理困扰的影响被BDNF多态性调节（调节中介指数= -0.19,[-0.48,-0.04]，p值≤0.05）。进一步将ACE分为AE和CM，只有AE的调节中介关系仍然显著（调节中介指数= -0.41,[-0.99,-0.10]，p值≤0.05）。结论：BDNF多态性与运动之间的相互作用可能是ace患者预防或减少心理困扰的合适干预目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;