Maternal mental disorders, psychotropic drugs, socioeconomic status, and offspring congenital anomalies.

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Satu-Maarit Björkstedt, Hannu Koponen, Hannu Kautiainen, Mika Gissler M, P Pennanen, Johan G Eriksson, Merja K Laine
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引用次数: 0

Abstract

Objective: To evaluate whether there is an association between maternal mental health, purchase of psychotropic drugs, socioeconomic status and major congenital anomalies in offspring.

Methods: A register-based cohort study of 6189 Finnish primiparous women who had a singleton delivery between 2009 and 2015. Data on pregnancy and delivery outcomes, psychiatric diagnosis, prescription drug purchases and offspring congenital anomalies were obtained from Finnish national registers.

Results: Severe depressive disorders were diagnosed in 2.0% of women and severe anxiety disorders in 1.1%. During pregnancy, 9.6% of women purchased psychotropic drugs. Of these women, 5.7% delivered an offspring with a major congenital anomaly. Women who purchased psychotropic drugs in pregnancy had an increased risk of delivering a child with major congenital anomalies compared with women who did not purchase psychotropic drugs. Multivariate regression analysis showed that purchase of benzodiazepines increased the risk of major congenital anomalies (odds ratio 2.11 [95% confidence interval 1.17 to 3.81]). Pregnant women purchasing psychotropic drugs more often lived alone and smoked, had higher body mass index, and had lower annual income and educational attainment than women not purchasing psychotropic drugs.

Conclusions: Benzodiazepine use, but not socioeconomic status, may be associated with major congenital abnormalities in offspring.

母亲精神障碍、精神药物、社会经济地位与后代先天性异常。
目的:探讨产妇心理健康状况、精神药物购买情况、社会经济状况与子女主要先天性异常是否存在相关性。方法:对2009年至2015年间发生单胎分娩的6189名芬兰孕妇进行了一项基于登记的队列研究。有关怀孕和分娩结果、精神病诊断、处方药购买和后代先天性异常的数据来自芬兰国家登记册。结果:重度抑郁障碍占2.0%,重度焦虑障碍占1.1%。在怀孕期间,9.6%的妇女购买了精神药物。在这些女性中,5.7%的人生出了患有严重先天性异常的后代。与没有购买精神药物的妇女相比,在怀孕期间购买精神药物的妇女分娩患有严重先天性畸形的儿童的风险增加。多因素回归分析显示,购买苯二氮卓类药物增加了重大先天性异常的风险(优势比2.11[95%可信区间1.17 ~ 3.81])。与未购买精神药物的孕妇相比,购买精神药物的孕妇独居、吸烟、体重指数较高、年收入和受教育程度较低。结论:苯二氮卓类药物的使用,而不是社会经济地位,可能与后代的主要先天性异常有关。
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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