Association of diet quality scores with risk of metabolic-associated fatty liver disease in Iranian population: a nested case-control study.

IF 1.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2025-01-13 eCollection Date: 2025-06-01 DOI:10.1007/s40200-024-01544-x

Ehsaneh Taheri, Yusuf Yilmaz, Fereshteh Ghorat, Alireza Moslem, Mohammad Reza Zali

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引用次数: 0

Abstract

Background and aim: A healthy diet has been recommended for non-alcoholic fatty liver disease (NAFLD). We aim to investigate the associations of diet quality indices with the risk of developingmetabolic-associated fatty liver disease (MAFLD).

Methods: We conducted this nested case-control study by recruiting 968 cases with MAFLD and 964 controls from the participants of the baseline phase of the Sabzevar Persian Cohort Study (SPCS). MAFLD was defined as having a fatty liver index ≥ 60 plus at least one of the following: overweight or obese, Type II diabetes mellitus, or evidence of metabolic dysregulation. Healthy Eating Index-2015 (HEI-2015) and Alternative Healthy Eating Index-2010 (AHEI-2010) were calculated from a validated food frequency questionnaire. We estimated the associations of HEI-2015 and AHEI-2010 with MAFLD risk using multivariable logistic regression.

Results: Among those in the highest relative to the lowest quintile of HEI-2015 and AHEI-2010, the multivariable-adjusted odds ratios (OR) were 0.45 (95% CI [confidence interval] 0.29-0.69; P _trend = 0.002) and 0.55 (95% CI 0.35-0.85; P _trend = 0.04), respectively.

Conclusion: The results of our study suggest that there is a significant associationbetween adherence to a healthy diet, indicated by a higher score of HEI or AHEI, and a reduced likelihood of developingMAFLD.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-024-01544-x.

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饮食质量评分与伊朗人群代谢相关脂肪肝风险的关联：一项巢式病例对照研究

背景和目的：非酒精性脂肪性肝病（NAFLD）推荐健康饮食。我们的目的是研究饮食质量指标与发生代谢性脂肪性肝病（MAFLD）风险的关系。方法：我们从Sabzevar波斯队列研究（SPCS）基线阶段的参与者中招募了968例MAFLD患者和964例对照患者，进行了巢式病例对照研究。MAFLD被定义为脂肪肝指数≥60加上以下至少一项：超重或肥胖，II型糖尿病，或有代谢失调的证据。健康饮食指数-2015 （HEI-2015）和替代健康饮食指数-2010 （AHEI-2010）是根据经过验证的食物频率问卷计算得出的。我们使用多变量逻辑回归估计了HEI-2015和AHEI-2010与MAFLD风险的关系。结果：在HEI-2015和AHEI-2010中相对于最低五分位数的最高五分位数中，多变量校正优势比（OR）为0.45 (95% CI[置信区间]0.29-0.69；P趋势= 0.002)和0.55 (95% CI 0.35-0.85；P趋势= 0.04)。结论：我们的研究结果表明，坚持健康饮食（HEI或AHEI得分较高）与降低发生mald的可能性之间存在显著关联。补充资料：在线版本提供补充资料，网址为10.1007/s40200-024-01544-x。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.