Metal-Organic Frameworks MIL-101(Fe) and MIL-53(Al) as Efficient Adsorbents for Dispersive Micro-Solid-Phase Extraction of Sorafenib in Plasma and Wastewater, Coupled with HPLC-UV Analysis.

IF 1.5 4区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of chromatographic science Pub Date : 2025-01-14 DOI:10.1093/chromsci/bmaf003

Azra Takhvar, Somaye Akbari, Effat Souri, Reza Ahmadkhaniha, Ali Morsali, Mohammad Reza Khoshayand, Mohsen Amini, Alireza Taheri

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Abstract

In the present study, metal-organic frameworks, MIL-101(Fe) and MIL-53(Al), were synthesized under solvothermal conditions and were characterized by Fourier transform infrared spectroscopy, X-ray energy diffraction spectroscopy and scanning electron microscopy. The synthesized metal-organic frameworks were utilized for the purpose of dispersive micro-solid phase extraction of sorafenib in both human plasma and wastewater, which was subsequently followed by high performance liquid chromatography with ultraviolet determination. Parameters affecting extraction efficacy including adsorbent amount, ionic strength, pH, type of elution solvent, adsorption and desorption time were optimized. Under optimal experimental conditions, the linearity in human plasma and wastewater was achieved in the range of 0.25-5.00 and 0.01-0.20 μg/mL, respectively. The extraction recovery for MIL-101(Fe) and MIL-53(Al), respectively, was calculated in human plasma and wastewater and found to be in the range of 86.27-99.47%.

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金属-有机骨架MIL-101（Fe）和MIL-53（Al）作为分散微固相萃取血浆和废水中索拉非尼的高效吸附剂，并结合HPLC-UV分析。

本研究在溶剂热条件下合成了金属有机骨架MIL-101（Fe）和MIL-53(Al)，并用傅里叶变换红外光谱、x射线能量衍射光谱和扫描电镜对其进行了表征。利用合成的金属-有机框架对人体血浆和废水中的索拉非尼进行分散微固相萃取，并进行高效液相色谱紫外测定。对吸附剂用量、离子强度、pH、洗脱溶剂类型、吸附脱附时间等影响萃取效果的参数进行了优化。在最佳实验条件下，血药浓度在0.25 ~ 5.00和0.01 ~ 0.20 μg/mL范围内呈线性关系。计算了MIL-101（Fe）和MIL-53（Al）在人血浆和废水中的萃取回收率，分别为86.27 ~ 99.47%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of chromatographic science 化学-分析化学

CiteScore

2.90

自引率

7.70%

发文量

审稿时长

5.6 months

期刊介绍： The Journal of Chromatographic Science is devoted to the dissemination of information concerning all methods of chromatographic analysis. The standard manuscript is a description of recent original research that covers any or all phases of a specific separation problem, principle, or method. Manuscripts which have a high degree of novelty and fundamental significance to the field of separation science are particularly encouraged. It is expected the authors will clearly state in the Introduction how their method compares in some markedly new and improved way to previous published related methods. Analytical performance characteristics of new methods including sensitivity, tested limits of detection or quantification, accuracy, precision, and specificity should be provided. Manuscripts which describe a straightforward extension of a known analytical method or an application to a previously analyzed and/or uncomplicated sample matrix will not normally be reviewed favorably. Manuscripts in which mass spectrometry is the dominant analytical method and chromatography is of marked secondary importance may be declined.