Sleep quality and physical fitness as modifiable contributors of fatigue in childhood cancer survivors.

IF 3.1 2区医学 Q2 ONCOLOGY

Journal of Cancer Survivorship Pub Date : 2025-01-17 DOI:10.1007/s11764-024-01741-w

Deveny Vanrusselt, Charlotte Sleurs, Nel Van Ermengem, Astrid Torrekens, Jurgen Lemiere, Sabine Verschueren, Anne Uyttebroeck

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引用次数: 0

Abstract

Purpose: Advances in cancer treatment have increased childhood cancer patient's survival rates. However, many childhood cancer survivors (CCS) face long-term effects such as fatigue. This study assessed fatigue in CCS and healthy controls (HCs), its contributors, and associated outcomes.

Methods: This cross-sectional study included 90 CCS and 55 age and sex-matched HCs. Fatigue was measured using the Pediatric Quality of Life Multidimensional Fatigue Scale, and modifiable contributors included sleep quality (Pittsburgh Sleep Quality Index [PSQI]) and physical fitness (VO₂ peak during a treadmill test). Quality of life (QoL) and emotional and cognitive functioning were evaluated using the Pediatric Quality of Life Inventory, Beck Depression Inventory II, Cognitive Failure Questionnaire, and the Impact of Event Scale-Revised. Stepwise linear regressions identified predictors of general, sleep/rest, cognitive, and total fatigue.

Results: General, cognitive, and total fatigue were significantly higher in CCS compared to HCs (44.7% vs. 23%, p < .001; cognitive: 64.7% vs. 29.3%, p < .001; total fatigue: 56.5% vs. 25%, p < .001). Sex, PSQI, PSQI × sex, and PSQI × VO₂ were significant predictors for general fatigue, PSQI and PSQI × VO₂ for cognitive fatigue, and PSQI for sleep/rest and total fatigue. Cognitive and total fatigue correlated most strongly with cognitive and work-related functioning, whereas general and sleep/rest fatigue were more related to psychosocial functioning.

Conclusion: Fatigue is highly prevalent among CCS, with distinct factors influencing general, sleep/rest, cognitive, and total fatigue. Female survivors, those with poorer sleep quality and lower physical fitness, are at risk.

Implications for cancer survivors: This study underscores the need for tailored interventions for each type of fatigue. Improving sleep quality, physical fitness, and psychological well-being may contribute to reducing fatigue and enhancing overall quality of life in CCS.

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睡眠质量和身体健康是儿童癌症幸存者疲劳的可变因素。

目的：癌症治疗的进步提高了儿童癌症患者的生存率。然而，许多儿童癌症幸存者（CCS）面临着长期的影响，如疲劳。本研究评估了CCS和健康对照（hc）的疲劳、其影响因素和相关结果。方法：本横断面研究包括90例CCS和55例年龄和性别匹配的hcc。使用儿科生活质量多维疲劳量表测量疲劳，可修改的因素包括睡眠质量（匹兹堡睡眠质量指数[PSQI]）和身体健康（跑步机测试期间的VO2峰值）。使用儿童生活质量量表、贝克抑郁量表、认知失败问卷和事件影响量表对生活质量（QoL）、情绪和认知功能进行评估。逐步线性回归确定了一般、睡眠/休息、认知和总疲劳的预测因子。结果：CCS患者的一般疲劳、认知疲劳和总疲劳明显高于hc患者（44.7% vs. 23%）。结论：疲劳在CCS患者中非常普遍，影响一般疲劳、睡眠/休息、认知疲劳和总疲劳的因素明显。那些睡眠质量较差、身体素质较差的女性幸存者面临风险。对癌症幸存者的启示：这项研究强调需要针对每种类型的疲劳进行量身定制的干预。改善睡眠质量、身体健康和心理健康可能有助于减少疲劳，提高CCS患者的整体生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cancer Survivorship ONCOLOGY-

CiteScore

7.00

自引率

10.80%

发文量

149

审稿时长

>12 weeks

期刊介绍： Cancer survivorship is a worldwide concern. The aim of this multidisciplinary journal is to provide a global forum for new knowledge related to cancer survivorship. The journal publishes peer-reviewed papers relevant to improving the understanding, prevention, and management of the multiple areas related to cancer survivorship that can affect quality of care, access to care, longevity, and quality of life. It is a forum for research on humans (both laboratory and clinical), clinical studies, systematic and meta-analytic literature reviews, policy studies, and in rare situations case studies as long as they provide a new observation that should be followed up on to improve outcomes related to cancer survivors. Published articles represent a broad range of fields including oncology, primary care, physical medicine and rehabilitation, many other medical and nursing specialties, nursing, health services research, physical and occupational therapy, public health, behavioral medicine, psychology, social work, evidence-based policy, health economics, biobehavioral mechanisms, and qualitative analyses. The journal focuses exclusively on adult cancer survivors, young adult cancer survivors, and childhood cancer survivors who are young adults. Submissions must target those diagnosed with and treated for cancer.