Shari David, Ana S Costa, Christian Hohenfeld, Sandro Romanzetti, Shahram Mirzazade, Jennifer Pahl, Luisa Haberl, Kai M Schneider, Axel Kilders, Thomas Eggermann, Christian Trautwein, Frank Hildebrand, Jörg B Schulz, Kathrin Reetz, Alexa Haeger
{"title":"Modulating effects of fitness and physical activity on Alzheimer's disease: Implications from a six-month randomized controlled sports intervention.","authors":"Shari David, Ana S Costa, Christian Hohenfeld, Sandro Romanzetti, Shahram Mirzazade, Jennifer Pahl, Luisa Haberl, Kai M Schneider, Axel Kilders, Thomas Eggermann, Christian Trautwein, Frank Hildebrand, Jörg B Schulz, Kathrin Reetz, Alexa Haeger","doi":"10.1177/13872877241303764","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Physical activity and fitness are major targets in Alzheimer's disease (AD) preventive research. However, current research is heterogeneous and often disregards the relationship between these parameters and disease outcomes.</p><p><strong>Objective: </strong>To assess the effects of physical activity and fitness on AD within the context of a multicomponent sports intervention.</p><p><strong>Methods: </strong>46 participants with early-stage AD (mean age 70 ± 7 years, 18 women, mean Montreal Cognitive Assessment (MoCA) score 19±5) were included in a six-month randomized controlled trial (Dementia-MOVE), participating in either a multicomponent sports intervention or a control condition with a psychoeducational program. The modulating effect of fitness and physical activity changes on AD outcome parameters such as cognition, function and cerebral brain structure from 3T-MRI were examined using multiple linear regression analyses.</p><p><strong>Results: </strong>An increase in VO<sub>2</sub>max was associated with assignment to the intervention group (<i>p </i>= 0.016), lower baseline fitness (<i>p </i>= 0.001), and an increased rate of physical activity (<i>p </i>= 0.046). Only in the intervention group, ΔVO<sub>2</sub>max had a beneficial modulating effect on the MoCA score (<i>p </i>= 0.039), the executive functions (<i>p </i>= 0.017) and regional brain volumes of the temporal lobe, e.g., the hippocampus (<i>p </i>= 0.044). High daily step count was associated with preserved executive functions (<i>p </i>= 0.001), and caregivers' quality of life (<i>p</i> ≤ 0.001) in the overall sample.</p><p><strong>Conclusions: </strong>Our results confirm that multicomponent exercise improves cardiorespiratory fitness in AD, which is associated with advantageous developments in cognitive performance and preservation of brain structure. These findings suggest that especially patients with comparably worse cognition and fitness benefit and should be encouraged for activity engagement.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"552-569"},"PeriodicalIF":3.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13872877241303764","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Physical activity and fitness are major targets in Alzheimer's disease (AD) preventive research. However, current research is heterogeneous and often disregards the relationship between these parameters and disease outcomes.
Objective: To assess the effects of physical activity and fitness on AD within the context of a multicomponent sports intervention.
Methods: 46 participants with early-stage AD (mean age 70 ± 7 years, 18 women, mean Montreal Cognitive Assessment (MoCA) score 19±5) were included in a six-month randomized controlled trial (Dementia-MOVE), participating in either a multicomponent sports intervention or a control condition with a psychoeducational program. The modulating effect of fitness and physical activity changes on AD outcome parameters such as cognition, function and cerebral brain structure from 3T-MRI were examined using multiple linear regression analyses.
Results: An increase in VO2max was associated with assignment to the intervention group (p = 0.016), lower baseline fitness (p = 0.001), and an increased rate of physical activity (p = 0.046). Only in the intervention group, ΔVO2max had a beneficial modulating effect on the MoCA score (p = 0.039), the executive functions (p = 0.017) and regional brain volumes of the temporal lobe, e.g., the hippocampus (p = 0.044). High daily step count was associated with preserved executive functions (p = 0.001), and caregivers' quality of life (p ≤ 0.001) in the overall sample.
Conclusions: Our results confirm that multicomponent exercise improves cardiorespiratory fitness in AD, which is associated with advantageous developments in cognitive performance and preservation of brain structure. These findings suggest that especially patients with comparably worse cognition and fitness benefit and should be encouraged for activity engagement.
期刊介绍：
The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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